Registration Dossier
Registration Dossier
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EC number: 203-103-0 | CAS number: 103-34-4
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Original reference not yet available.
Data source
Reference
- Reference Type:
- publication
- Title:
- Occupational allergic contact dermatitis caused by thiourea compounds.
- Author:
- Kanerva L, Estlander T, and Jolanski R.
- Year:
- 1 994
- Bibliographic source:
- Contact dermatitis, 31 : 242-248.
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Patch test on 5 patients with allergic contact dermatitis.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Di(morpholin-4-yl) disulphide
- EC Number:
- 203-103-0
- EC Name:
- Di(morpholin-4-yl) disulphide
- Cas Number:
- 103-34-4
- Molecular formula:
- C8H16N2O2S2
- IUPAC Name:
- 4-(morpholin-4-yldisulfanyl)morpholine
- Details on test material:
- no data available
Constituent 1
Method
- Type of population:
- occupational
- Subjects:
- During 1985-1991, 5 pateints with allergic patch test reactions caused by thiourea compounds.
- Clinical history:
- no data
- Controls:
- no data
- Route of administration:
- dermal
- Details on study design:
- no
Results and discussion
- Results of examinations:
- None patient gave positive result with DTDM.
Applicant's summary and conclusion
- Conclusions:
- Result : Negative.
- Executive summary:
During 1985-1991, 423 patients were tested with a rubbers chemical series (eg DTDM) by patch test. No patient showed a positive reaction with DTDM.
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