Registration Dossier
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EC number: 203-103-0 | CAS number: 103-34-4
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The acute toxicity of DTDM was assessed with Oncorhynchus mykiss in a study performed similarly to OECD testing guideline 203. No data are given relative to GLP criteria.
The fish were exposed to nominal test concentrations between 0.25 and 4 mg/L under flow-through conditions during 7 days. The mean measured concentrations were maintained between 80 and 120 % of nominal. LC50-96 h was estimated using measured concentrations as being equal to 3.68 mg/L.
Mortality in control, temperatures, pH range and dissolved oxygen concentration were reported and in agreement with the guideline requirements.
DTDM 96-hour LC50=3.5 mg/1 (95% C.I.= 2.7-4.4 mg/1) and NOEC of 1.0 mg/l.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 3.68 mg/L
Additional information
The acute toxicity of DTDM was assessed with Oncorhynchus mykiss in a study performed similarly to OECD testing guideline 203.
The fish were exposed to nominal test concentrations between 0.25 and 4 mg/L under flow-through conditions during 7 days. The mean measured concentrations were maintained between 80 and 120 % of nominal. LC50-96 h was estimated using measured concentrations as being equal to 3.68 mg/L. Mortality in control, temperatures, pH range and dissolved oxygen concentration were reported and in agreement with the guideline requirements.
The acute toxicity of DTDM to Pimephales promelas was also assessed using the methods outlined by the Committee on Methods for Toxicity Tests with Aquatic Organisms. Water quality parameters of temperature, pH and ammonia were measured throughout the test and were within acceptable limits. Dissolved oxygen values in the control chamber were above 40% saturation throughout the study, but fell below this level in certain test solutions during the fast 24-48 hours of testing. However, mortality rates remained basically unchanged during this period. The results of the four day static fish toxicity study are summarized below.
DTDM
96-hour LC50=3.5 mg/1
95% C.I.= 2.7-4.4 mg/1
NOEC of 1.0 mg/l.
These two results show that DTDM can be considered as toxic to freshwater fish.
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