Registration Dossier

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

Currently viewing:

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study according to internal BASF standards

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1973
Report date:
1973

Materials and methods

Principles of method if other than guideline:
Method: other: BASF-Test
GLP compliance:
no
Test type:
other: BASF Method

Test material

Constituent 1
Chemical structure
Reference substance name:
Disodium [2,2'-bi-1H-indole]-3,3'-diolate
EC Number:
212-974-6
EC Name:
Disodium [2,2'-bi-1H-indole]-3,3'-diolate
Cas Number:
894-86-0
Molecular formula:
C16H12N2O2.2Na C16H10N2Na2O2
IUPAC Name:
disodium 1H,1'H-[2,2'-biindole]-3,3'-bis(olate)
Details on test material:
- Name of test material (as cited in study report): Indigoküpe BASF 60% Körner
- Substance type: preparation
- Physical state: solid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
no data

Administration / exposure

Route of administration:
inhalation: aerosol
Type of inhalation exposure:
not specified
Vehicle:
other: unchanged (no vehicle)
Details on inhalation exposure:
Inhalation by means of vapor saturated at 20°C for 8 hours. To achieve saturation, air was fed through an approx. 5 cm deep layer of the product.
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
8 h
Concentrations:
no data
No. of animals per sex per dose:
12 rats
Control animals:
no
Details on study design:
- Duration of observation period following administration: 7 days
- Frequency of observations and weighing: -
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other:
Statistics:
NA

Results and discussion

Preliminary study:
NA
Mortality:
no deaths
Clinical signs:
other: no effects
Body weight:
no data
Gross pathology:
no effects

Any other information on results incl. tables

8 hours inhalation of an indigo saturated atmosphere did not lead to any deaths in rats (0/12)

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
8 hours inhalation of an indigo saturated athmosphere did not lead to any deaths in rats (0/12)