Registration Dossier
Registration Dossier
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EC number: 218-871-2 | CAS number: 2269-22-9
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Dominant for toxicokinetic behaviour is sec-butanol formed upon hydrolysis of aluminium tri-sec-butylate, whereas aluminium hydroxide is hardly bioavailable having absorption rates of 1% and less. Neither aluminium hydroxide nor sec-butanol does bioaccumulate. Sec-butanol is readily absorbed via oral or inhalative uptake but less via dermal. Metabolism and excretion of systemically available sec-butanol occurs via methyl ethyl ketone as metabolite and is efficient and fast.
Details are in the attachment to section 13
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 100
- Absorption rate - dermal (%):
- 10
- Absorption rate - inhalation (%):
- 100
Additional information
In biota aluminium tri-sec-butylate immediately hydrolyses to aluminium hydroxide and 2-butanol in the presence of moisture or water. Whereas absorption of aluminium hydroxide via oral, dermal and inhalation pathways is considered low (in the range of 1 % and less) the opposite holds true for sec-butanol with absorption rates of estimated 100% via oral and inhalation route and up to 10% estimated via dermal route. Thus, the toxicokinetics of aluminium tri-sec-butylate is dominated by the organic moiety sec-butanol. Bioaccumulation is neither a concern for aluminium hydroxide nor for sec-butanol (metabolism and excretion is efficient and rapid).
For explanation for using surrogate data in a weight of evidence approach see section 13 IUCLID.
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