Registration Dossier
Registration Dossier
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EC number: 202-940-9 | CAS number: 101-41-7
Endpoint summary
Administrative data
Description of key information
Hydrolysis
The half-life and base catalyzed second order hydrolysis rate constant was determined using a structure estimation method of the test chemical (authoritative databases, 2017). The second order hydrolysis rate constant of test chemical was determined to be 0.21L/mol-sec with a corresponding half-lives of 1.0 yrs and 37 days at pH 7 and 8, respectively. Based on the half-life values, it is concluded that the test chemical is not hydrolysable.
Additional information
Hydrolysis
Experimental study and predicted data of the test chemical were reviewed for the hydrolysis end point which are summarized as below:
In an experimental key study from authoritative databases (2017),the half-life and base catalyzed second order hydrolysis rate constant was determined using a structure estimation method of the test chemical. The second order hydrolysis rate constant of test chemical was determined to be 0.21L/mol-sec with a corresponding half-lives of 1.0 yrs and 37 days at pH 7 and 8, respectively.
For the test chemical, HYDROWIN v2.00 program of Estimation Programs Interface (2018) prediction model was used to predict the hydrolysis half-life of test chemical. The estimated half-life of test chemical was evaluated to be 1.024 yrs at pH 7.0 and 37.401 days at pH 8.0 (at 25ᵒC) respectively.
On the basis of the above results of test chemical(fromauthoritative and modelling databases,2017), it can be concluded that the hydrolysis half-life value of test chemicalranges from 37 days to 1 yr (at pH 8.0 and 7.0), respectively, indicating that the test chemical is not hydrolysable in water.
Waiver statement
Hydrolysis endpoint can also be considered for waiver as per in accordance with column 2 of Annex VIII of the REACH regulation, testing for this endpoint is scientifically not necessary and does not need to be conducted since the test chemical is readily biodegradable.
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