Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 219-542-6 | CAS number: 2458-08-4
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
“Protein binding by OASIS” and “Skin sensitization alerts implemented by Toxtree” are two profilers relevant for skin sensitization.
“Protein binding by OASIS” includes categories or chemical mechanism of protein binding particularly relevant for skin sensitization. Toxtree decision rule system identifies alerts for skin sensitization using a SMARTS pattern based approach. “Skin sensitization alerts” is based on the identification of structural alerts for skin sensitization as described in Enoch et al (Enoch SJ et al., SAR & QSAR Environ Res. 2008;19(5-6), 555-78).
According to “Protein binding by OASIS”, all the target chemicals were classified as “no binding”, since they did not answer any of the categorization criteria. No structural alerts were identified for the five biliary acids according to “Skin sensitization alerts”. In fact no alerts were identified for acyl transfer agent, nor for a potential Michael acceptor, nor for Schiff base formation, nor for potential second-order nucleophilic aliphatic substitution reaction, nor for nucleophilic aromatic substitution reaction.
Thus, it was concluded thatthe five biliary acids are NOT SKIN SENSITIZER.
Justification for selection of skin sensitisation endpoint:
“Protein binding by OASIS” and “Skin sensitization alerts implemented by Toxtree” are two validated profilers relevant for skin sensitization.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Based on the results of a QSAR prediction, 12 -ketochenodeoxycholic acid is not classified for skin seinsitization, according to Regulation 1272/2008/EC.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
