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EC number: 909-586-0
CAS number: -
oral toxicity study comparable to OECD 401 was performed with fumed
alumina in female and male
rats. This study has been performed at the Hazelton
Laboratories, Inc.. Fumed alumina was administered by a single oral
gavage to seven groups of five males and five females per group at dose
levels of 1000, 1590, 2510, 3980, 6310, 10000 and 15900 mg/kg bw after
an overnight food withdrawal.
monitored during this study included mortality and clinical signs of
possible intoxication.Clinical observations were performed
on all animals immediately after dosing, at 1, 4 and 24 hours after
dosing and daily for 14 days thereafter.
During the 14 days of the observation
period, there was no mortality or clinical signs of intoxication related
to aluminium oxide administration at dose range from 1000 mg/kg to 10000
Clinical signs of depression, laboured
respiration, and piloerection (males) were noted immediately and hunched
appearance was noted at 24 hours post-administration of the highest dose
No significant sex differences were
noted among animals in the sensitivity to the administered compound or
during the recovery period. Animals appeared normal by day 7 (females)
and day 8 (males).
Macroscopic examination at the end of
the observation period did not reveal any aluminium-related changes of
the internal organs of the aluminium treated animals compared to the
Under the conditions of this study,
the acute oral median lethal dose (LD50) of the fumed alumina is above
15900 mg/kg bw in both females and males rats.
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