Registration Dossier
Registration Dossier
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EC number: 604-453-0 | CAS number: 145022-45-3
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
In order to study a possible skin sensitisation potential of EMIM Methansulfonate, three groups each of five female mice were treated daily with the test item at concentrations of 25, 50, and 100% (w/v) in dimethylformamide by topical application to the dorsum of each ear once daily for three consecutive days. All treated animals survived the scheduled study period and no signs of systemic toxicity or local skin irritation were observed.
In this study Stimulation Indices (S.I.) of 1.56, 2.46, and 2.98 were determined with the test item at concentrations of 25, 50 and 100% (w/v) in dimethylformamide, respectively. A clear dose response was observed. The EC3 value calculated was about 100% (w/v). [BASF, 2011]
Migrated from Short description of key information:
The test item EMIM Methansulfonate was found to be a weak skin sensitiser in the Local Lymphe Node Assay (OECD 429).
Justification for classification or non-classification
EMIM Methansulfonate is considered to be skin sensitising (EU: R43; GHS: cat.1 H317) according to the criteria of EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No 1272/2008.
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