Registration Dossier
Registration Dossier
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EC number: 203-383-4 | CAS number: 106-31-0
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2002
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted under GLP conformance according to the procedures outlined in :OECD Guideline No. 111 [1]EEC's Annex V. Part C.7. [2] EPA's Chemical Fate Guidleline, [3] EPA's Pesticide Assessment Guidelines.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Butyric anhydride
- EC Number:
- 203-383-4
- EC Name:
- Butyric anhydride
- Cas Number:
- 106-31-0
- Molecular formula:
- C8H14O3
- IUPAC Name:
- butanoyl butanoate
- Details on test material:
- The Hydrolysis testing was performed in eight different matrices, each containing approximately two percent acetonitrile: distilled deionized water (DDW); aquatic culture water (ACW); distilled water buffered at pH 4, 7 and 9; aquatic culture water buffered at pH 4, 7 and 9. Each matrix contained 1 percent by volume of acetonitrile prior to the introduction of the test substance.
A test substance stock solution was prepared by weiging approximately 1.0 gram of the test substance into 10-ml volumetric flasks and diluting with acetonitrile. The working test sytems were prepared at aproximately 1000 mg/L. Each test system was prepared in triplicate.
Constituent 1
Study design
- Analytical monitoring:
- yes
- Details on sampling:
- The working test systems were prepared at approximately 1000 mg/L by trasnferring 0.5 mls of the test substance stock solution into a labeled 50 ml volumetric flask containing approximately 45 ml of a the matrix of study, adjusted to the desired pH. Each flask wasthen diluted to volume with the appropriate solvent. Aliquots of the test solutions were distributed between several GC vials and each was analyzed as is using GC/FID.
- Buffers:
- ph4 Buffer- (.01 M Sodium Acetate in water with 1% Acetonitrile)
pH7 Buffer- (0.1 M Potassium Phosphate dibasic anhydrous in water with 1% acetonitrile)
pH 9 Buffer- (0.025 M Sodium Borate in water, with 1% acetonitrile - Details on test conditions:
- Test temperature was maintained at 22 C throughout the analysis. Time was measure using a hand timer.
- Number of replicates:
- 3 replicates per matrix run.
Results and discussion
- Transformation products:
- yes
Identity of transformation products
- No.:
- #1
Reference
- Reference substance name:
- Unnamed
- IUPAC name:
- butanoic acid
- Inventory number:
- InventoryMultipleMappingImpl [inventoryEntryValue=EC 203-532-3]
- CAS number:
- 107-92-6
- Identity:
- n-butyric acid
- Molecular formula:
- C4H8O2
- Molecular weight:
- 88.105
- SMILES notation:
- CCCC(=O)O
- InChl:
- InChI=1/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)
- Details on hydrolysis and appearance of transformation product(s):
- In every analysis, the butyric anhydride hydrolyzed completely to butyric acid.
Dissipation DT50 of parent compoundopen allclose all
- pH:
- 7
- Temp.:
- 22 °C
- Hydrolysis rate constant:
- 0.039 - 0.041 min-1
- DT50:
- 16.9 - 17.8 min
- Type:
- not specified
- Remarks on result:
- other: Distilled Deionized Water
- pH:
- 7
- Temp.:
- 22 °C
- Hydrolysis rate constant:
- 0.037 - 0.04 min-1
- DT50:
- 17.3 - 18.9 min
- Type:
- not specified
- Remarks on result:
- other: Aquatic Culture Water
- pH:
- 4
- Temp.:
- 22 °C
- Hydrolysis rate constant:
- 0.038 - 0.043 min-1
- DT50:
- 16.2 - 18 min
- Type:
- not specified
- Remarks on result:
- other: distilled Deionized Water
- pH:
- 7
- Temp.:
- 22 °C
- Hydrolysis rate constant:
- 0.078 - 0.132 min-1
- DT50:
- 5.27 - 8.9 min
- Type:
- not specified
- Remarks on result:
- other: Distilled deionized water
- pH:
- 9
- Temp.:
- 22 °C
- Hydrolysis rate constant:
- 0.381 - 0.411 min-1
- DT50:
- 1.69 - 2.56 min
- Type:
- not specified
- Remarks on result:
- other: Distilled Deionized Water
- pH:
- 4
- Temp.:
- 22 °C
- Hydrolysis rate constant:
- 0.04 - 0.041 min-1
- DT50:
- 16.7 - 17.2 min
- Type:
- not specified
- Remarks on result:
- other: Aquatic Culture Water
- pH:
- 7
- Temp.:
- 22 °C
- Hydrolysis rate constant:
- 0.101 - 0.105 min-1
- DT50:
- 6.48 - 6.86 min
- Type:
- not specified
- Remarks on result:
- other: Aquatic culture Water
- pH:
- 9
- Temp.:
- 22 °C
- Hydrolysis rate constant:
- 0.336 - 0.341 min-1
- DT50:
- 2.03 - 2.06 min
- Type:
- not specified
- Remarks on result:
- other: Aquatic Culture Water
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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