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Physical & Chemical properties

Water solubility

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Description of key information

The water solubility was determined to be 1.26 mg/L at 20 °C and pH 6.6.

Key value for chemical safety assessment

Water solubility:
1.26 mg/L
at the temperature of:
20 °C

Additional information

The water solubility of the test material was investigated in accordance with the standardised guidelines OECD 105 and EU Method A.6 under GLP conditions using the column elution method. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).

The flow rate was adjusted to approximately 30 mL/h (i.e. 0.52 mL/min) in the first experiment. The result obtained was confirmed by a second experiment using half the flow rate of the first experiment (approximately 0.26 mL/min).  The column eluate was sampled (six samples/experiment) in time intervals of at least 1 hour to determine the concentration of the test material. Total elution time was 96.5 hours. The quantification was performed by HPLC.

The water solubility of the test material at 20 °C was determined to be 1.26 mg/L (± 0.02 mg/L).