Registration Dossier
Registration Dossier
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EC number: 203-702-7 | CAS number: 109-76-2
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
The inhibition of the degradation activity of activated sludge is not anticipated when introduced in appropriately low concentrations.
Key value for chemical safety assessment
Additional information
The inhibiting effect of trimethylenediamine (CAS 109 -76 -2) on the respiration activity of domestic activated sludge was investigated in a study according to OECD 209. The 30 min EC20 was determined to be approximately 950 mg/L (BASF AG, 2002; Study No. 02/0218/08/1).
The results of a growth inhibition study with Pseudomonas putida according to German Industrial Standard DIN 38412, part 8 (BASF AG, 1989; Study No. 9/1890498) show a higher sensitivity than the OECD 209 study. The 17 -h EC10 were determined to be 45 mg/L. According to the REACH Guidance R.10, test results according to Bringmann & Kühn (1980) which is equivalent to DIN 38412 , part 8 should only be used if no other test results are available. Therefore the short-term respiration study according to OECD 209 will be used for the derivation of the PNEC.
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