Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 913-635-1 | CAS number: -
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Published in a peer-reviewed paper, limited reporting, but otherwise acceptable for assessment.
Data source
Reference
- Reference Type:
- publication
- Title:
- Inhalation of calcium chloride aerosols in complex therapy of pulmonary tuberculosis.
- Author:
- Vinnikov PL, Slepova RI, Sataev IF
- Year:
- 1 962
- Bibliographic source:
- Kazan Med Zh. , 4, 7-9
Materials and methods
- Study type:
- other: tuberculosis patients treatment
- Endpoint addressed:
- acute toxicity: inhalation
- Principles of method if other than guideline:
- Sixty five tuberculosis patients (51 males, 14 females; age from below 30 till over 50) were treated with aerosol inhalations of 2-5% aqueous solution of calcium chloride. The number of inhalations varied from below 10 (24 patients), till over 30 (2 patients). Clinical signs are reported.
- GLP compliance:
- no
Test material
- Reference substance name:
- Calcium chloride
- EC Number:
- 233-140-8
- EC Name:
- Calcium chloride
- Cas Number:
- 10043-52-4
- Molecular formula:
- CaCl2
- IUPAC Name:
- calcium dichloride
- Details on test material:
- No data.
Constituent 1
Method
- Type of population:
- other: tuberculosis patients
- Subjects:
- - Number of subjects exposed: 65
- Sex: 51 males, 14 females
- Age: below 30: 17, from 31 to 50: 39, over 50: 9
- Race: unknown
- Demographic information: unknown
- Known diseases: tuberculosis - Ethical approval:
- not specified
- Route of exposure:
- inhalation
- Reason of exposure:
- intentional
- Exposure assessment:
- not specified
- Examinations:
- - Other: symptomatic assessment (cough duration and frequency, sputum expellance, sputum nature etc.)
Results and discussion
- Clinical signs:
- Several patients reported irritation of mucos membranes of pharinx and throat and unpleasant sensation in mouth already after the first inhalations. However, the frequency of such cases was described as minor by the authors. Overall calcium chloride inhalations were said to have beneficiary effects on disease symptoms (improved quality of spatum, decreased amounts of spatum, improved ease of spatum expellance, decreased frequency of coughing).
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
