Registration Dossier

Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

The aquatic toxicity of the registered substance, (-)-(3aR,5aS,9aS,9bR)-3a,6,6,9a-Tetramethyldodecahydronaphtho[2,1-b]furan, was assessed using data performed on the registered substance and on source substance, (±)-(3aR*,5aS*,9aS*,9bR*)-3a,6,6,9a-Tetramethyldodecahydronaphtho[2,1-b]furan. This compound is the racemic form of the registered substance. Based on structural similarity and common physico-chemical properties between these isomers, and the same results on the observed toxicity to aquatic invertebrates (no acute effect up to the attainable limit of solubility in test medium, see ECHA disseminated dossier of the read-across substance EC# 223 -118 -6), this source substance is considered adequate for read-across purposes (see IUCLID section 13 for justification).

No toxic effects were observed up to the attainable limit of solubility of the registered and/or source substances in acute studies for the three aquatic trophic levels (fish, aquatic invertebrates and algae) and no long-term effect was observed in the algae study at the maximum attainable mean test concentration. Therefore, based on a read-across approach, the registered substance is not expected to be hazardous to pelagic organisms. The chemical safety assessment for environment is not necessary.

In accordance with column 2 of REACH Annex VIII, the activated sludge respiration inhibition test does not need to be conducted because the substance is readily biodegradable, according to the OECD 301F study. The applied test concentrations (100 mg/L) are in the range of concentrations that can be expected in the influent of a sewage treatment plant, and no inhibition effects on the activity of microorganisms was observed. This statement is supported by one study, performed on the registered substance, according to DIN Guideline 38412 part 27 with GLP statement. The test substance had no inhibitory effect on the respiration rate of Pseudomonas putida after the incubation period of 30 min at the test item concentration of 10 g/L.

Additional information