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Physical & Chemical properties

Melting point / freezing point

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Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From 03/07/2012 to 24/07/2012
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
The study was conducted according to an internationally recognised method, and under GLP. The substance is considered to be adequately characterised with its purity. Therefore full validation applies.
Qualifier:
according to
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Deviations:
no
Qualifier:
according to
Guideline:
other: BS4634; Determination of melting point
GLP compliance:
yes (incl. certificate)
Remarks:
Inspected on 15th and 16th November 2011 / Signed on 1st May 2012
Type of method:
capillary method
Key result
Melting / freezing pt.:
75.1 °C
Atm. press.:
97.2 kPa
Remarks on result:
other: accuracy +/-0.5 °C

Results

   t (initial)  t (final)  t (melting average)
 Preliminary test :  348.1 K  349.2 K  348.7 K
 Determination 1 :  347.6 K  348.3 K  348.0 K
 Determination 2 :  347.6 K  348.2 K  347.9 K
 mean of det.1 and 2  347.6 K  348.3 K  

The difference between initial and final melting temperature is within accuracy, therefore the average of final temperatures in the main determinations is retained = 348.3 K

Executive summary:

The melting point of the test substance was determined under GLP according to BS4634 (listed in OECD 102/EU A1 guideline), capillary method. Two main runs were performed, and the mean final temperature was retained.

Melting (i.e. solid-liquid transition) occurs at the single temperature of 75.1°C (348.3K).

Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2012
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
The study was conducted according to an internationally recognised method. The substance is considered to be adequately characterised with its purity. Therefore full validation applies.
Qualifier:
according to
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Deviations:
no
Qualifier:
according to
Guideline:
other: BS4634; Determination of melting point
GLP compliance:
no
Type of method:
capillary method
Melting / freezing pt.:
63.9 °C
Atm. press.:
96.8 kPa
Remarks on result:
other: accuracy +/-0.5 °C

Results

   t (initial)  t (final)  t (melting average)
 Preliminary test :  337.5 K  339 K  338.3 K
 Determination 1 :  336.2 K  337.1 K  336.7 K
 Determination 2 :  336 K  337 K  336.5 K
 mean of det.1 and 2  336.1 K  337.1 K  

The difference between initial and final melting temperature is within accuracy, therefore the average of final temperatures in the main determinations is retained = 337.1 K

Executive summary:

The melting point of the test substance was determined according to BS4634 (listed in OECD 102/EU A1 guideline), capillary method. Two main runs were performed, and the mean final temperature was retained.

Melting (i.e. solid-liquid transition) occurs at the single temperature of 63.9°C (337.1K).

Description of key information

Melting (i.e. solid-liquid transition) occurs at a single temperature (i.e. not a range) between 63.9 and 75.1°C, depending on purity.

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:
75.1 °C

Additional information

Two fully reliable experimental studies, conducted according to a recognized OECD/EC method, are available. Both are considered as key studies, as relating to two different purities. The result for the highest purity is retained as key data for purpose of CSA.