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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Remarks:
Type of genotoxicity: gene mutation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
secondary source
Title:
GENOTOXIC ACTIVITIES OF BENZAMIDINE AND ITS N-HYDROXYLATED METABOLITE BENZAMIDOXIME IN SALMONELLA TYPHIMURIUM AND MAMMALIAN CELLS
Author:
CLEMENT,B, SCHMEZER,P, WEBER,H, SCHLEHOFER,JR, SCHMITT,S AND POOL,BL
Year:
1988
Bibliographic source:
J. CANCER RES. CLIN. ONCOL. 114(4):363-368

Materials and methods

Principles of method if other than guideline:
Guideline not reported.
GLP compliance:
not specified
Type of assay:
bacterial reverse mutation assay

Test material

Constituent 1
Chemical structure
Reference substance name:
Benzamide oxime
EC Number:
210-361-8
EC Name:
Benzamide oxime
Cas Number:
613-92-3
Molecular formula:
C7H8N2O
IUPAC Name:
N-hydroxybenzenecarboximidamide

Method

Species / strainopen allclose all
Species / strain / cell type:
S. typhimurium TA 98
Species / strain / cell type:
S. typhimurium TA 100
Metabolic activation:
with and without
Test concentrations with justification for top dose:
1-10 UMOL/PLATE

Results and discussion

Test results
Species / strain:
S. typhimurium, other: TA98, TA100
Metabolic activation:
with and without
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
not specified

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information):
negative