Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Hazard for aquatic organisms

Freshwater

Hazard assessment conclusion:
PNEC aqua (freshwater)
PNEC value:
0.69 mg/L
Assessment factor:
10
Extrapolation method:
assessment factor
PNEC freshwater (intermittent releases):
6.9 mg/L

Marine water

Hazard assessment conclusion:
PNEC aqua (marine water)
PNEC value:
0.069 mg/L
Assessment factor:
100
Extrapolation method:
assessment factor

STP

Hazard assessment conclusion:
PNEC STP
PNEC value:
400 mg/L
Assessment factor:
1
Extrapolation method:
assessment factor

Sediment (freshwater)

Hazard assessment conclusion:
PNEC sediment (freshwater)
PNEC value:
15.762 mg/kg sediment dw
Extrapolation method:
equilibrium partitioning method

Sediment (marine water)

Hazard assessment conclusion:
PNEC sediment (marine water)
PNEC value:
1.576 mg/kg sediment dw
Extrapolation method:
equilibrium partitioning method

Hazard for air

Hazard for terrestrial organisms

Soil

Hazard assessment conclusion:
PNEC soil
PNEC value:
0.73 mg/kg soil dw
Assessment factor:
1 000

Hazard for predators

Secondary poisoning

Hazard assessment conclusion:
no potential for bioaccumulation

Additional information

Conclusion on classification

From the EU RAR for trisodiumnitrilotriacetate (EINECS 225 -768 -6), final report, 2005, which also contains the relevant ecotox data for nitrilotriacetic acid (the full report is attached in section 13). The relevant chapter here is:

1.4 CLASSIFICATION

Classification according to Annex I

Class of danger:       none

R-Phrase:               none

The classification of NTA is not included in Annex I to Derective 67/548/EEC.

Proposed classification (only environmental part)

For the classification of biodegradation, the available laboratory tests with uncomplexed NTA should not be used, because biodegradation of this chelator is strongly dependent on the metal speciation. Studies on the degradation in biological treatment plants as well as degradation tests conducted in river water reveal that the degradation properties of NTA (its metal complexes respectively) are comparable with a readily degradable substance. In addition the substance has no bioaccumulation potential.

In tests on the acute toxicity on fish and daphnia effects were only observed when NTA was present in over-stoichiometric concentrations compared to the content of metal ions. The lowest LC50 values were 98 mg/l for both trophic levels.

Results of algae growth inhibition tests have to be interpreted carefully, because the observed effects are mainly cause by nutrient deficiency, which is an artefact and not relevant for the environment. Tests with increased concentrations of nutrient metals (where nutrient deficiency is suppressed) reveal that intrinsic toxicity of NTA is expected only at concentrations far above 10 mg/l.

Considering all results, a classification of Na3NTA for the environment is not recommended.

See for further details the full RAR which is attached under section 13