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Short-term toxicity to aquatic invertebrates

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Description of key information

The short-term toxicity of L-arginine-HCl to aquatic invertebrates (daphnia) is estimated by read-across from L-arginine.

The test results for acute toxicity of L-arginine to daphnia magna were:

EC50 = 1.8 g/l; EC100 = 5.6 g/l; NOEC (mobility) was estimated to be 1.0 g/l and NOEC (condition) was estimated to be < 1.0 g/l.

These results are converted based upon the retion of the molecular weight.

The results applying for Arg-HCl are: EC50 = 2.2 g/l; EC100 = 6.8 g/l; NOEC (mobility) was estimated to be 1.2 g/l and NOEC (condition) was estimated to be < 1.2 g/l.

Key value for chemical safety assessment

EC50/LC50 for freshwater invertebrates:
2.2 g/L

Additional information

A limit test according to OECD 202 did not show any adverse effects to Daphnia magna at a test concentration of 1 g/l. A subsequent test according to OECD 202 with higher test concentrations showed the following results:

EC50 = 1.8 g/l; EC100 = 5.6 g/l; NOEC (mobility) was estimated to be 1.0 g/l and NOEC (condition) was estimated to be < 1.0 g/l.

There is weight of evidence from the behaviour of L-arginine-HCl in aqueous solution that read-across from L-arginine to L-arginine-HCl is justified for the endpoint short-term toxicity to aquatic invertebrates.

These results from Arg are converted to Arg-HCL based upon the retion of the molecular weight.

The results applying for Arg-HCl are: EC50 = 2.2 g/l; EC100 = 6.8 g/l; NOEC (mobility) was estimated to be 1.2 g/l and NOEC (condition) was estimated to be < 1.2 g/l.