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Ecotoxicological information

Short-term toxicity to fish

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Description of key information

The short-term toxicity of L-arginine-HCl to fish is estimated by read-across from L-arginine.

The test results for acute toxicity of L-arginine to fish were: LC50 = 2.8 g/l; LC 100 = 5.6 g/l; NOEC (mortality) = 1.8 g/l; NOEC (condition) = 1.0 g/l.

These results are converted bases upon the ratio of the molecular weight. The results applying for Arg-HCl are.

LC50 = 3.4 g/l; LC 100 = 6.8 g/l; NOEC (mortality) = 2.2 g/l; NOEC (condition) = 1.2 g/l.

Key value for chemical safety assessment

LC50 for freshwater fish:
3.4 g/L

Additional information

A limit test according to OECD 203 did not show any adverse effects to fish at a test concentration of 1 g/L L-arginine. A subsequent test with L-arginine according to OECD 203 with higher test concentrations showed the following results: LC50 = 2.8 g/l; LC 100 = 5.6 g/l; NOEC (mortality) = 1.8 g/l; NOEC (condition) = 1.0 g/l.

These results are converted bases upon the ratio of the molecular weight. The results applying for Arg-HCl are.

LC50 = 3.4 g/l; LC 100 = 6.8 g/l; NOEC (mortality) = 2.2 g/l; NOEC (condition) = 1.2 g/l.

There is weight of evidence from the behaviour of L-arginine-HCl in aqueous solution as well as from QSAR modelling that read-across from L-arginine to L-arginine-HCL is justified for the endpoint short-term toxicity to fish.