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Environmental fate & pathways

Adsorption / desorption

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Description of key information

Absorption to solid phase is not expected.

Key value for chemical safety assessment

Koc at 20 °C:
0.006

Additional information

In accordance with REACH Annex VIII section 9.3.1. column 2 as well as REACH Annex IX section 9.3.3. column 2 the study on adsorption/desorption screening (required in section 9.3.1. column 1) does not need to be conducted as the substance has a low log Kow as well as the substance and its degradation products decompose rapidly. Adsorption to solid soil phase is not expected. From the water surface L-arginine-HCl will not evaporate into the atmosphere.

Despite of that Koc was estimated by calculation by EpiSuite's KOCWIN model. Read-across was performed from L-arginine to L-arginine-HCl.

L-arginine-HCl as such is not a natural constituent of peptides and proteins. L-arginine-HCL is the salt resulting from the reaction of the basic L-arginine with HCl. Due to is higher water solubility L-arginine-HCl is often preferably applied than L-arginine, in particular when bioavailability is desired property for the intended use.

L-arginine-HCl dissociates in aqueous solution to ionic L-arginine as well as H+and Cl-. The inorganic ions resulting from physiological concentrations are not of concern for toxicokinetics as the “background” concentration in the body is by magnitudes higher.

EpiSuite's KOCWIN model is not applicable for L-arginine-HCL as the model attributes the substance to a wrong chemical substance class. Consequently, the Koc estimate would be outside the program's prediction domain.

The suitability of the model was assessed for L-arginine and it was concluded that L-arginine is considered to be inside the applicability domain of the EpiSuite KOCWIN model.