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EC number: 601-327-7 | CAS number: 114772-54-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 25 July 1995 to 31 July 1995
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP, Guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- OECD guideline not specified.
- GLP compliance:
- yes
Test material
- Reference substance name:
- 4'-(bromomethyl)-[1,1'-biphenyl]-2-carbonitrile
- EC Number:
- 601-327-7
- Cas Number:
- 114772-54-2
- Molecular formula:
- C14H10BrN
- IUPAC Name:
- 4'-(bromomethyl)-[1,1'-biphenyl]-2-carbonitrile
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- Test compound/batch: SR 48941 2/batch 5SNP501.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Three New Zealand White rabbits, two males and one female, identified by vendor attached plastic ear tag or implanted microship and study animal identification number written with indelible ink pen inside the right ear and housed one per cage.
- Source: Hazleton Research Products, Inc
- Age at study initiation: three to six months old
- Weight at study initiation: rabbits were weighed on Day-1 and body weights ranged from 3.0 to 3.5 kg.
- Housing: the rabbits were caged in an environmentally controlled room
- Diet : 125 grams/rabbit/day of Purina Certified High Fiber Rabbit Chow No. 5325 Lot 17 May 95 2A and 15 June 95 1B
- Water (e.g. ad libitum): municipal water (via an automatic watering system)
ENVIRONMENTAL CONDITIONS
- Temperature: 64-68°F
- Relative Humidity: 40-60 %
- Photoperiod (hrs dark / hrs light): 12 hour light/dark cycles.
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: No control article was used; untreated sited served as controls.
- Amount / concentration applied:
- 500 mg of solid compound
- Duration of treatment / exposure:
- 4 hrs
- Observation period:
- 72 hrs
- Number of animals:
- 3, two males and one female
- Details on study design:
- On Day 1 of the study, 500 mg of solid compound was applied to a 6 cm² area on the right side of sheared backs, the left side serving as control. The areas were covered with gauze, the backs wrapped with a semi-occlusive dressing, and Elizabethan collars donned for approximately 4 hrs.
OBSERVED EFFECTS AND MORTALITY
The rabbits were observed at least once daily throughout the study, until termination on Day 7, for changes in appearance and behavior and mortality.
BODY WEIGHTS
The rabbits were weighed on Day -1.
OBSERVATION AND SCORING
Control and treated sites were assessed for erythema and edema 1 hr (Day 1), then 24 (Day 2), 48 (Day 3) and 72 (Day 4) hrs after dressing removal.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 1, 24, 48 and 72 hrs
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 1, 24, 48 and 72 hrs
- Score:
- 0
- Max. score:
- 0
- Irritant / corrosive response data:
- SR 48941 (batch 5SNP501) was without response in all animals. Mean values were not calculated due to lack of observable cutaneous irritation.
- Other effects:
- No clinical signs of toxicity were observed in any rabbit and no deaths occurred during the study.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based on the results of this study, SR 48941 (batch 5SNP501) is not a reportable skin irritant.
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