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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
activated sludge respiration inhibition testing
Type of information:
experimental study
Adequacy of study:
key study
Study period:
March 1993
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Guideline Study without GLP

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1993
Report date:
1993

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
3-[(2-hydroxyethyl)amino]propionamide
EC Number:
248-211-9
EC Name:
3-[(2-hydroxyethyl)amino]propionamide
Cas Number:
27076-30-8
Molecular formula:
C5H12N2O2
IUPAC Name:
N~3~-(2-hydroxyethyl)-beta-alaninamide
Test material form:
other: Colourless slightly viscous liquid

Sampling and analysis

Analytical monitoring:
no

Test solutions

Vehicle:
no

Test organisms

Test organisms (species):
activated sludge
Details on inoculum:
The aeration Stage of Severn Trent Water PLC Sewage Treatment Plant, belper, Derbyshire

Study design

Test type:
static
Water media type:
freshwater
Limit test:
yes
Total exposure duration:
3 h

Test conditions

Details on test conditions:
The sample was maintained at 2l"c with continuous aeration
and used on the day of collection. The pH was buffered to
pH 7.2 with sod'ium hydroxìde solutjon and the suspended
soljds level equaì to 3.8 g/1 prior to use.
Reference substance (positive control):
yes
Remarks:
3,5-dichlorophenol

Results and discussion

Effect concentrations
Duration:
3 h
Dose descriptor:
EC50
Effect conc.:
> 1 000 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
inhibition of total respiration
Remarks:
respiration rate
Results with reference substance (positive control):
EC50 (3 hour contact time) = 10.5 mg/L

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
The EC50 (3 hour contact time) was reported as > 1000 mg/L.
Executive summary:

The EC50 (3 hour contact time) was reported as > 1000 mg/L.