Registration Dossier

Ecotoxicological information

Long-term toxicity to fish

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
fish early-life stage toxicity
Data waiving:
other justification
Justification for data waiving:
other:

Description of key information

The chemical safety assessment according to Annex I of Regulation (EC) No 1907/2006 does not indicate the need to further investigate the effects on fish.

Key value for chemical safety assessment

Additional information

There are no long-term toxicity studies to fish available for Reaction mass of 2-(3,4-dimethyl-1H-pyrazol-1-yl)succinic acid and 2-(4,5-dimethyl-1H-pyrazol-1-yl)succinic acid. However, short-term toxicity studies are available for all three trophic levels, fish, daphnia and algae, and no effects were observed up to the highest test concentration of 100 mg/L. According to the “Guidance on information requirements and chemical safety assessment Chapter R.7b: Endpoint specific guidance”, if invertebrates are likely to be more sensitive than fish and algae or the relative sensitivity of invertebrates cannot be predicted, long-term testing on Daphnia sp. should be preferred instead of fish (ECHA, 2017). Therefore, in this case, a long-term toxicity study was conducted with Daphnia magna. As the NOEC values obtained with Daphnia as well as with algae are clearly above 1 mg/L, a long-term fish study is not considered necessary for hazard assessment.