Registration Dossier
Registration Dossier
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EC number: 233-466-0 | CAS number: 10191-41-0
Endpoint summary
Administrative data
Description of key information
Additional information
Since no studies on aquatic toxicity of DL-Alpha-Tocopherol are available all data refer to the precursor of DL-Alpha-Tocopheryl acetate.
acute toxicity in fish:
For fish a read across study performed in the structural analogue DL-alpha tocopheryl acetate is available: After 28 d of exposure against juvenile rainbow trout in an OECD 215 an NOEC of > 100 mg/l for survival was deviated.
acute toxicioty in daphnia:
The data refer to DL-alpha-tocopheryl acetate a precursor of DL-alpha-tocopherol. The toxicity of DL-Alpha-Tocopheryl acetatetowardsDaphnia magnawas investigated according to OECD Guideline 202 under GLP conditions (Maetzler, 2000). The measured 48h-EC50 was 20.6 mg/l. The study was considered to be the key study.
The acute toxicity study is also for DL-alpha-tocopheryl acetate toD. magnaavailable: Toxicity was investigated in a static test system following German standard DIN 38412, part L11. The 48h EC0 was 500 mg/l and the 48h EC50 was >500 mg/l (BASF AG, 1988). The study was considered to be a supporting study.
acute toxicity in algae:
The toxicity of the substance towardsSelenastrum capricornutumwas tested according to OECD Guideline 201 under GLP conditions. (Grade, 1995). The 72h-EC50 of DL-Alpha-Tocopheryl acetate towardsSelenastrum capricornutumwas > 25.8 mg/l (measured) and thus clearly above the limit of water solubility.
acute toxicity against mircoorganisms:
Read across data are available for DL-Alpha-Tocopheryl acetate, a precursor of the substance.The respiration rate of microorganisms in presence of DL-Alpha-Tocopheryl acetate was tested by a oxygen consumption test according to ROBRA focusing on the respiration ofPseudomonas putida. After 30 minutes an EC50 > 10000 mg/l was determined (BASF AG, 1991).
long term toxicity in fish.:
A read across study for fish performed in the structural analogue DL-alpha tocopheryl acetate is available: After 28 d of exposure against juvenile rainbow trouts in an OECD 215 a NOEC of > 100 mg/l for survival was deviated.
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