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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Study period:
1971
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1971
Report date:
1971

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: USDA Regulation (Federal Register 34, No. 64, April 4, 1969)
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Naphthalenesulfonic acids, branched and linear Bu derivs., sodium salts
EC Number:
293-346-9
EC Name:
Naphthalenesulfonic acids, branched and linear Bu derivs., sodium salts
Cas Number:
91078-64-7
Molecular formula:
Not applicable (a generic molecular formula can not be provided for this specific UVCB substance)
IUPAC Name:
Naphthalenesulfonic acids, branched and linear Bu derivs., sodium salts
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder

Test animals / tissue source

Species:
rabbit

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
other: irritation
Basis:
animal: 21 and 27
Time point:
24/48/72 h
Score:
0
Remarks on result:
other: Irritation effects: positive after 24 h; negative after 48 h and 72 h.
Irritation parameter:
other: irritation
Basis:
animal: 22, 23, 24 and 26
Time point:
24/48/72 h
Score:
0
Remarks on result:
other: Irritation effects: positive after 24, 48 and 72 h.

Any other information on results incl. tables

The results are shown in the following table.

Animal number

Irritant effect on the eye

after

24 hours

after

48 hours

after

72 hours

21

pos.

neg.

neg.

22

pos.

pos.

pos.

23

pos.

pos.

pos.

24

pos.

pos.

pos.

26

pos.

pos.

pos.

27

pos.

neg.

neg.

Result: distinct irritant effect on the mucosa

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritating to eyes) based on GHS criteria
Conclusions:
The test item caused distinct irritation of the mucosa of the eye in the rabbit.

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