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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Study period:
1971
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1971
Report date:
1971

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: USDA Regulation (Federal Register 34, No. 64, April 4, 1969)
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Naphthalenesulfonic acids, branched and linear Bu derivs., sodium salts
EC Number:
293-346-9
EC Name:
Naphthalenesulfonic acids, branched and linear Bu derivs., sodium salts
Cas Number:
91078-64-7
Molecular formula:
Not applicable (a generic molecular formula can not be provided for this specific UVCB substance)
IUPAC Name:
Naphthalenesulfonic acids, branched and linear Bu derivs., sodium salts
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder

Test animals

Species:
rabbit

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
other: redness and swelling
Basis:
animal: 1 (intact) and 15 (scarified)
Time point:
24 h
Score:
0
Reversibility:
not specified
Irritation parameter:
other: redness and swelling
Basis:
animal: 1 (intact) and 15 (scarified)
Time point:
72 h
Score:
0
Reversibility:
not specified
Irritation parameter:
other: redness and swelling
Basis:
animal: 2 (intact) and 16 (scarified)
Time point:
24 h
Score:
0.75
Reversibility:
not specified
Irritation parameter:
other: redness and swelling
Basis:
animal: 2 (intact) and 16 (scarified)
Time point:
72 h
Score:
0.75
Reversibility:
not specified
Irritation parameter:
other: redness and swelling
Basis:
animal: 3 (intact) and 17 (scarified)
Time point:
24 h
Score:
1
Reversibility:
not specified
Irritation parameter:
other: redness and swelling
Basis:
animal: 3 (intact) and 17 (scarified)
Time point:
72 h
Score:
1
Reversibility:
not specified
Irritation parameter:
other: redness and swelling
Basis:
animal: 4 (intact) and 18 (scarified)
Time point:
24 h
Score:
1
Reversibility:
not specified
Irritation parameter:
other: redness and swelling
Basis:
animal: 4 (intact) and 18 (scarified)
Time point:
72 h
Score:
1
Reversibility:
not specified
Irritation parameter:
other: redness and swelling
Basis:
animal: 5 (intact) and 19 (scarified)
Time point:
24 h
Score:
0.25
Reversibility:
not specified
Irritation parameter:
other: redness and swelling
Basis:
animal: 5 (intact) and 19 (scarified)
Time point:
72 h
Score:
0.25
Reversibility:
not specified
Irritation parameter:
other: redness and swelling
Basis:
animal: 6 (intact) and 20 (scarified)
Time point:
24 h
Score:
0.5
Reversibility:
not specified
Irritation parameter:
other: redness and swelling
Basis:
animal: 6 (intact) and 20 (scarified)
Time point:
72 h
Score:
0.5
Reversibility:
not specified

Any other information on results incl. tables

Irritant effect on the skin of rabbits

The results are summarized in the table below.

Animal number

Effect on the skin

Result

Skin

intact

Skin

scarified

after 24 hour

after 72 hours

intact

scarified

intact

scarified

1

15

R 0

R 0

R 0

R 0

0

S0

S 0

S 0

S 0

2

16

R 0

R 1

R 0

R 2

0.75

S 0

S 0

S 0

S 0

3

17

R 0

R 2

R 0

R 2

1.0

S 0

S 0

S 0

S 0

4

18

R 0

R 2

R 0

R 2

1.0

S 0

S 0

S 0

S 0

5

19

R 0

R 0

R 0

R 1

0.25

S 0

S 0

S 0

S 0

6

20

R 0

R 0

R 0

R 2

0.5

S 0

S 0

S 0

S 0

Result: no primary irritant effect

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The test item is not irritant.

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