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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Study period:
1971
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1971
Report date:
1971

Materials and methods

Principles of method if other than guideline:
Niessen, H., Tietz, H., Hecht, J. & Kimmerli, G. (1963) Arch. Toxikol., 20. 44
GLP compliance:
no
Test type:
other: dynamic and static nebulization inhalation

Test material

Constituent 1
Chemical structure
Reference substance name:
Naphthalenesulfonic acids, branched and linear Bu derivs., sodium salts
EC Number:
293-346-9
EC Name:
Naphthalenesulfonic acids, branched and linear Bu derivs., sodium salts
Cas Number:
91078-64-7
Molecular formula:
Not applicable (a generic molecular formula can not be provided for this specific UVCB substance)
IUPAC Name:
Naphthalenesulfonic acids, branched and linear Bu derivs., sodium salts
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Details on inhalation exposure:
Dynamic nebulization inhalation
Tests were performed using an apparatus for dynamic inhalation developed by ourselves. The compound was nebulized in a mixture of water and Lutrol
Static nebulization inhalation
The animals were held in 2m3 rooms and subjected for 4 hours over half-hour periods to the active ingredient nebulized as a solution in water and Lutrol (1:1). The observation period lasted 14 days and the following results were obtained.
Duration of exposure:
4 h
No. of animals per sex per dose:
20 rats were used for each test. We obtained the following results over an observation period of 2 weeks.

Results and discussion

Effect levelsopen allclose all
Sex:
female
Dose descriptor:
LC50
Effect level:
> 0.94 mg/L air
Based on:
test mat.
Exp. duration:
4 h
Sex:
male
Dose descriptor:
LC50
Effect level:
> 0.933 mg/L air
Based on:
test mat.
Exp. duration:
4 h

Any other information on results incl. tables

Dynamic nebulization inhalation

Air concentration

mg Erkantol BXG/1

Daily test

period in

hours

Number of

test days

Tox. Result

after 14 days

Theoretical

Analytically

determined

male rats

1.0

0.143

4

1

0/0/20

2.5

0.400

4

1

0/20/20

5.0

0.933

4

1

5/20/20

1.0

0.234

4

5

0/0/10

female rats

1.0

0.180

4

1

0/0/20

2.5

0.510

4

1

0/20/20

5.0

0.940

4

1

0/20/20

1.0

0.234

4

5

0/0/10

LC50 male rat 4 h exposure > 0.933 mg/1 air

LC50 male rat 5 x 4 h exposure>0.234 mg/1 air

LC50 female rat 4 h exposure > 0.940 mg/1 air

LC50 female rat 5 x 4 h exposure > 0.234 mg/1 air

At higher concentrations the animals exhibited a transient deterioration in their general health. The male rats were more sensitive than the females, and displayed labored breathing at the highest concentration

Static nebulization inhalation

Air concentration

mg Erkantol BXG/1

Animal

species

Tox. Result

after 14 days

Theoretical

Analytically

determined

1.0

0.108

rabbits

0/0/2

 

 

hamsters

0/0/5

 

 

rats

0/0/10

 

 

mice

0/0/20

 

 

 

 

2.0

0.173

rabbits

0/1/2

 

 

hamsters

0/5/5

 

 

rats

0/10/10

 

 

mice

0/0/20

 

 

 

 

5.0

0.864

rabbits

2/2/2

 

 

hamsters

2/5/5

 

 

rats

1/10/10

 

 

mice

0/20/20

Of those animals tested, the rabbits and hamsters were more sensitive than rats and mice. There were no irritant effects to the mucosa of the eye and nasal region.

Applicant's summary and conclusion

Interpretation of results:
Category 2 based on GHS criteria
Remarks:
Migrated information

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