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EC number: 248-326-4 | CAS number: 27213-90-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 1971
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
- Report date:
- 1971
Materials and methods
- Principles of method if other than guideline:
- Niessen, H., Tietz, H., Hecht, J. & Kimmerli, G. (1963) Arch. Toxikol., 20. 44
- GLP compliance:
- no
- Test type:
- other: dynamic and static nebulization inhalation
Test material
- Reference substance name:
- Naphthalenesulfonic acids, branched and linear Bu derivs., sodium salts
- EC Number:
- 293-346-9
- EC Name:
- Naphthalenesulfonic acids, branched and linear Bu derivs., sodium salts
- Cas Number:
- 91078-64-7
- Molecular formula:
- Not applicable (a generic molecular formula can not be provided for this specific UVCB substance)
- IUPAC Name:
- Naphthalenesulfonic acids, branched and linear Bu derivs., sodium salts
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Details on inhalation exposure:
- Dynamic nebulization inhalation
Tests were performed using an apparatus for dynamic inhalation developed by ourselves. The compound was nebulized in a mixture of water and Lutrol
Static nebulization inhalation
The animals were held in 2m3 rooms and subjected for 4 hours over half-hour periods to the active ingredient nebulized as a solution in water and Lutrol (1:1). The observation period lasted 14 days and the following results were obtained. - Duration of exposure:
- 4 h
- No. of animals per sex per dose:
- 20 rats were used for each test. We obtained the following results over an observation period of 2 weeks.
Results and discussion
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- LC50
- Effect level:
- > 0.94 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- > 0.933 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
Any other information on results incl. tables
Dynamic nebulization inhalation
Air concentration mg Erkantol BXG/1 |
Daily test period in hours |
Number of test days |
Tox. Result after 14 days |
|
Theoretical |
Analytically determined |
|||
male rats |
||||
1.0 |
0.143 |
4 |
1 |
0/0/20 |
2.5 |
0.400 |
4 |
1 |
0/20/20 |
5.0 |
0.933 |
4 |
1 |
5/20/20 |
1.0 |
0.234 |
4 |
5 |
0/0/10 |
female rats |
||||
1.0 |
0.180 |
4 |
1 |
0/0/20 |
2.5 |
0.510 |
4 |
1 |
0/20/20 |
5.0 |
0.940 |
4 |
1 |
0/20/20 |
1.0 |
0.234 |
4 |
5 |
0/0/10 |
LC50 male rat 4 h exposure > 0.933 mg/1 air
LC50 male rat 5 x 4 h exposure>0.234 mg/1 air
LC50 female rat 4 h exposure > 0.940 mg/1 air
LC50 female rat 5 x 4 h exposure > 0.234 mg/1 air
At higher concentrations the animals exhibited a transient deterioration in their general health. The male rats were more sensitive than the females, and displayed labored breathing at the highest concentration
Static nebulization inhalation
Air concentration mg Erkantol BXG/1 |
Animal species |
Tox. Result after 14 days |
|
Theoretical |
Analytically determined |
||
1.0 |
0.108 |
rabbits |
0/0/2 |
|
|
hamsters |
0/0/5 |
|
|
rats |
0/0/10 |
|
|
mice |
0/0/20 |
|
|
|
|
2.0 |
0.173 |
rabbits |
0/1/2 |
|
|
hamsters |
0/5/5 |
|
|
rats |
0/10/10 |
|
|
mice |
0/0/20 |
|
|
|
|
5.0 |
0.864 |
rabbits |
2/2/2 |
|
|
hamsters |
2/5/5 |
|
|
rats |
1/10/10 |
|
|
mice |
0/20/20 |
Of those animals tested, the rabbits and hamsters were more sensitive than rats and mice. There were no irritant effects to the mucosa of the eye and nasal region.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 based on GHS criteria
- Remarks:
- Migrated information
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