Sodium diisobutylnaphthalenesulphonate

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Study period:

1971

Reliability:

1 (reliable without restriction)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1971

Report date:

1971

Materials and methods

Principles of method if other than guideline:

Niessen, H., Tietz, H., Hecht, J. & Kimmerli, G. (1963) Arch. Toxikol., 20. 44

GLP compliance:

no

Test type:

other: dynamic and static nebulization inhalation

Test material

Test material information

Constituent 1

Reference substance name:

Naphthalenesulfonic acids, branched and linear Bu derivs., sodium salts

EC Number:

293-346-9

EC Name:

Naphthalenesulfonic acids, branched and linear Bu derivs., sodium salts

Cas Number:

91078-64-7

Molecular formula:

Not applicable (a generic molecular formula can not be provided for this specific UVCB substance)

IUPAC Name:

Naphthalenesulfonic acids, branched and linear Bu derivs., sodium salts

Test material form:

solid: particulate/powder

Remarks:

migrated information: powder

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Administration / exposure

Route of administration:

inhalation

Type of inhalation exposure:

not specified

Details on inhalation exposure:

Dynamic nebulization inhalation
Tests were performed using an apparatus for dynamic inhalation developed by ourselves. The compound was nebulized in a mixture of water and Lutrol
Static nebulization inhalation
The animals were held in 2m3 rooms and subjected for 4 hours over half-hour periods to the active ingredient nebulized as a solution in water and Lutrol (1:1). The observation period lasted 14 days and the following results were obtained.

Duration of exposure:

4 h

No. of animals per sex per dose:

20 rats were used for each test. We obtained the following results over an observation period of 2 weeks.

Results and discussion

Effect levels

Effect levels 1

Sex:

female

Dose descriptor:

LC50

Effect level:

> 0.94 mg/L air

Based on:

test mat.

Exp. duration:

4 h

Effect levels 2

Sex:

male

Dose descriptor:

LC50

Effect level:

> 0.933 mg/L air

Based on:

test mat.

Exp. duration:

4 h

Any other information on results incl. tables

Dynamic nebulization inhalation

Air concentration mg Erkantol BXG/1		Daily test period in hours	Number of test days	Tox. Result after 14 days
Theoretical	Analytically determined
male rats
1.0	0.143	4	1	0/0/20
2.5	0.400	4	1	0/20/20
5.0	0.933	4	1	5/20/20
1.0	0.234	4	5	0/0/10
female rats
1.0	0.180	4	1	0/0/20
2.5	0.510	4	1	0/20/20
5.0	0.940	4	1	0/20/20
1.0	0.234	4	5	0/0/10

LC50 male rat 4 h exposure > 0.933 mg/1 air

LC50 male rat 5 x 4 h exposure>0.234 mg/1 air

LC50 female rat 4 h exposure > 0.940 mg/1 air

LC50 female rat 5 x 4 h exposure > 0.234 mg/1 air

At higher concentrations the animals exhibited a transient deterioration in their general health. The male rats were more sensitive than the females, and displayed labored breathing at the highest concentration

Static nebulization inhalation

Air concentration mg Erkantol BXG/1		Animal species	Tox. Result after 14 days
Theoretical	Analytically determined
1.0	0.108	rabbits	0/0/2
		hamsters	0/0/5
		rats	0/0/10
		mice	0/0/20
2.0	0.173	rabbits	0/1/2
		hamsters	0/5/5
		rats	0/10/10
		mice	0/0/20
5.0	0.864	rabbits	2/2/2
		hamsters	2/5/5
		rats	1/10/10
		mice	0/20/20

Of those animals tested, the rabbits and hamsters were more sensitive than rats and mice. There were no irritant effects to the mucosa of the eye and nasal region.

Applicant's summary and conclusion

Interpretation of results:

Category 2 based on GHS criteria

Remarks:

Migrated information