Registration Dossier
Registration Dossier
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EC number: 248-326-4 | CAS number: 27213-90-7
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1970
- Reliability:
- 1 (reliable without restriction)
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The test item has been administered to rats at dose of 400, 800, 1600, 2000, 2500 e 3200 mg/kg bw by gavage.
- GLP compliance:
- no
- Test type:
- acute toxic class method
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- 400, 800, 1600, 2000, 2500 e 3200 mg/kg bw
- No. of animals per sex per dose:
- 400 mg/kg bw: 10 males and 10 females
800 mg/kg bw: 10 males and 10 females
1600 mg/kg bw: 20 males and 20 females
2000 mg/kg bw: 10 males and 10 females
2500 mg/kg bw: 10 males and 10 females
3200 mg/kg bw: 10 males and 10 females - Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 800 mg/kg bw
- Based on:
- test mat.
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- DL50 in male/female rats: 1800 mg/ kg bw
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 800 mg/kg bw
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1987
- Reliability:
- 1 (reliable without restriction)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- no
- Test type:
- acute toxic class method
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Route of administration:
- inhalation
- Type of inhalation exposure:
- nose/head only
- Duration of exposure:
- 4 h
- Concentrations:
- Group 1: 1.09 mg/L
Group 2: 3.49 mg/l
Group 3: 4.76 mg/L - No. of animals per sex per dose:
- 5 males and 5 females
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 3.82 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- LC50 for male and female rats is 3.82 mg/L/4h
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 3 820 mg/m³ air
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1970
- Reliability:
- 1 (reliable without restriction)
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The test item has been administered to rats at dose of 1000, 2000 and 4000 mg/kg bw.
- GLP compliance:
- no
- Test type:
- standard acute method
- Species:
- rabbit
- Strain:
- Vienna White
- Sex:
- male/female
- Vehicle:
- water
- Duration of exposure:
- 24 hours
- Doses:
- 1000, 2000 and 4000 mg/kg bw
- No. of animals per sex per dose:
- 1000 mg/kg: 2 males and 1 female
2000 mg/kg: 2 females and 1 male
4000 mg/kg: 4 males and 2 females - Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 3 000 mg/kg bw
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- LD50 for male/female rabbits is 3000 mg/kg.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 3 000 mg/kg bw
Additional information
The L(E)C50 values obtained in the experimental studies for substances with different CAS numbers are comparable by read-across.
Justification for selection of acute toxicity – oral endpoint
The two available experimental studies report similar results, which involve the same hazard classififcation.
Justification for selection of acute toxicity – inhalation endpoint
The selected study is the only study reporting an exact LC50 value.
Justification for selection of acute toxicity – dermal endpoint
The selected study is the only available for the dermal route.
Justification for classification or non-classification
Basing on the L(E)C50 values and according to Regulation 1272/2008/EC, the substance is classified as follows:
Acute Tox. 4, H302
Acute Tox. 4, H332
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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