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Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Older study by a recognised laboratory.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1978

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 406 (Skin Sensitisation)
Deviations:
not specified
GLP compliance:
not specified
Type of study:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

In vivo test system

Test animals

Species:
guinea pig
Strain:
other: SPF-derived, albino strain
Sex:
not specified

Study design: in vivo (non-LLNA)

Inductionopen allclose all
Route:
epicutaneous, occlusive
Vehicle:
other: dimethyl formamide
Concentration / amount:
10%, 1% and 0.1%
Challengeopen allclose all
Route:
epicutaneous, occlusive
Vehicle:
other: dimethyl formamide
Concentration / amount:
10%, 1% and 0.1%
Positive control substance(s):
not specified

Results and discussion

Positive control results:
No erythematous reactions were observed in either test or control animals.

In vivo (non-LLNA)

Results
Reading:
other:
Hours after challenge:
336
Group:
other:
Dose level:
1000mg/kg
No. with + reactions:
0
Total no. in group:
3
Remarks on result:
other: Reading: other:. . Hours after challenge: 336.0. Group: other:. Dose level: 1000mg/kg. No with. + reactions: 0.0. Total no. in groups: 3.0.

Applicant's summary and conclusion

Interpretation of results:
not sensitising
Remarks:
Migrated information
Executive summary:

Read across from bis(4 -fluorphenyl)ketone as it is analogous with 1,4'-bis(4-fluorobenzoyl)benzene in that it has:

equal number of chain ending identical inorganic groups.

structure with similar chain extending properties.

similar aquesous solubility properties