Registration Dossier
Registration Dossier
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EC number: 252-777-2 | CAS number: 35884-66-3
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
Skin sensitisation to TTP was determined in a guideline study (OECD TG 429, EU method B.42). TTP is a sensitiser. The submission substance is a Nickel complex with TTP as its ligand, which is expected to be rapidly released. Therefore NiL4 is found to be a sensitiser as well.
Migrated from Short description of key information:
Based on results for the surrogate substance, TTP, the submission substance is considered to be a sensitiser.
Respiratory sensitisation
Endpoint conclusion
- Additional information:
- Migrated from Short description of key information:
No information available
Justification for classification or non-classification
Based on the positive results of a skin sensitisation study of the surrogate substance TTP,
according to Regulation 1272/2008, the submission substance should be classified as skin sensitizer (Category 1) and labeled with H317: May cause an allergic skin reaction.
Based on an observed EC3 < 2% (SI at lowest tested concentration of 2.5% was 4.8) the substance is considered to be a strong sensitiser and a specific concentration limit of 0.1% (w/v) is set.
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