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Diss Factsheets
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EC number: 605-617-4 | CAS number: 17183-98-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Sept 1994
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Version / remarks:
- adopted 04 Apr 1984 Paris
- Deviations:
- yes
- Remarks:
- The test temperature was slightly lower than the range the guideline recommended
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: all concentrations
- Sampling method: Samples for the analysis by HPLC were taken at 0; 24; 48; 72 and 96 hours - Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: 2.00 g of the test substance were dissolved in 20 L of tap water in the test aquaria. This solution was constantly stirred for about 24 hours and then filtered. - Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
- Common name: Zebrafish
- Source: German bred; Distributor: Westaquarium, Zierfischzüchterei, Bad Lauterberg
- Length at study initiation (length definition, mean, range and SD): 2.5 cm estimated
ACCLIMATION
- Acclimation period: 4 weeks
- Feeding frequency during acclimation: twice a day
- Health during acclimation (any mortality observed): no mortality was observed - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Test temperature:
- 19.9 - 20.5 °C
- pH:
- 8.4 - 8.6
- Dissolved oxygen:
- 7.3 - 9.0
- Nominal and measured concentrations:
- 100 mg/L nominal
0.04 mg/L measured - Details on test conditions:
- TEST SYSTEM
- Test vessel: 25 L glass aquaria
- Aeration: no
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 2
- No. of vessels per control (replicates): 2
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: according to guideline
OTHER TEST CONDITIONS
- Photoperiod: 12 h light/12 h dark
EFFECT PARAMETERS MEASURED (with observation intervals if applicable):
- Mortality and visual abnormalities were recorded every 24 h. - Reference substance (positive control):
- no
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 0.04 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: Saturated solution
- Sublethal observations / clinical signs:
Table 1: Cumulative mortality
Nominal concentration of ZK 10882 (in mg/I) 3 hours 6 hours 24 hours 48 hours 72 hours 96 hours (water control) 0 0 0 0 0 0 0 100 0 0 0 0 0 0 - Validity criteria fulfilled:
- yes
- Conclusions:
- The LC50/96 hours of ZK 10882 is higher than a saturated solution with a concentration of 0.04 mg/L.
- Executive summary:
The purpose of this study was to determine LC50/96 hours of the substance 6 -Chlor-Chlormethldien to the Zebra fish (Brachydanio rerio).
Ten fish were used for the test solution and ten for the contral group. The fish were exposed to one concentration of the test substance and the dilution water for aperiod of 96 hours. The test solution was prepared by suspending 100 mg/L in dilution water. After stirring the suspension was filtered and the filtrate was used as test solution. Mortalities and visual abnormalities were recorded at approximately 3, 6, 24, 48, 72 and 96 hours. Samples for the analysis by HPLC were taken at 0; 24; 48; 72 and 96 hours . The concentrations found in the samples reached only 0.04 ± 0.01 mg/L. This indicates that the test substance is only poorly soluble in water. No mortality was observed in the control as well as in the test concentration during the whole exposure time and no fish showed any abnormal behaviour. Accordingly, the LC50/96 hours of the test substance is higher than a saturated solution with a concentration of 0.04 mg/L.
Reference
Description of key information
The LC50 of the substance is reported to be > 0.04 mg/L measured over a period of 96 h with Danio rerio as test organism.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Dose descriptor:
- LC50
- Effect concentration:
- 0.04 mg/L
Additional information
"shold read: > 0.04 mg/L"
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