Registration Dossier
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EC number: 203-841-3 | CAS number: 111-17-1
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 20.06.2003
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- ca. 0.19
- Temp.:
- 25.1 °C
- pH:
- ca. 2.9
- Details on results:
- Octanol-water partition coefficient was determined in two test repetitions. Test results in details are presented in Table 1. The value of octanol-water partition coefficient is an average over 6 measurements and equal to logPow=0.19 with standard deviation = 0.011 and greatest difference between log Pow measurements = 0.04.
- Conclusions:
- The n-octanol/water partition coefficient was determined to be 0.19 at 25.1°C, pH 2.9 (OECD TG 107, flask method).
Reference
Test results are present in Table 1:
|
Pow |
Log Pow |
|||
Measurement values |
Average |
Overall average |
|||
Measurement condition-1 |
a |
1.61 |
0.21 |
0.20 |
0.19 |
b |
1.54 |
0.19 |
|||
Measurement condition-2 |
a |
1.55 |
0.19 |
0.19 |
|
b |
1.54 |
0.19 |
|||
Measurement condition-3 |
a |
1.52 |
0.18 |
0.18 |
|
b |
1.49 |
0.17 |
|||
Description of key information
The n-octanol/water partition coefficient was determined to be 0.19 at 25.1°C, pH 2.9 (OECD TG 107, flask method).
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 0.19
- at the temperature of:
- 25.1 °C
Additional information
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