Tetrachlorophthalic anhydride

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Meets generally accepted scientific standards, acceptable with restrictions

Data source

Reference

Reference 1

Reference Type:

study report

Title:

Unnamed

Year:

1975

Reference 2

Reference Type:

publication

Title:

HPV Chemicals Challenge Program. Revised test plan for 4,5,6,7-tetrachloro-1,3-isobenzofurandione CAS no. 117-08-8

Author:

Solutia Inc.

Year:

2003

Bibliographic source:

Received OPPT CBIC 2003 May 22 (201-14481A, IUCLID Data set received OPPT CBIC 2003 May 22 (201-14481B)

Reference 3

Reference Type:

publication

Title:

Effect of tetrachlorophthalic anhydride on hepatic microsomal metabolism in rats and mice.

Author:

Ridley WP, Warren J, Nair RS

Year:

1988

Bibliographic source:

J Toxicol Environ Health 24: 217-227

Materials and methods

Principles of method if other than guideline:

Groups of 5 male and 5 female rats per dose were exposed to atmospheres containing either 3.16 or 3.60 mg/l test material for 4 hours. Air concentrations were generated using a ferris wheel generator to create a dust and passing clean air through the generator at 30 l/min to an 80 l glass and steel chamber containing the animals. Particle size means were calculated. Rats were held for 14 days for observation, then sacrificed and necropsied. Physical signs were recorded.

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Tetrachlorophthalic anhydride

EC Number:

204-171-4

EC Name:

Tetrachlorophthalic anhydride

Cas Number:

117-08-8

Molecular formula:

C8Cl4O3

IUPAC Name:

tetrachloro-1,3-dihydro-2-benzofuran-1,3-dione

Details on test material:

- Name of test material (as cited in study report): Tetrachlorophthalic anhydride
- Analytical purity: 99%

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

no data

Administration / exposure

Route of administration:

inhalation: dust

Type of inhalation exposure:

not specified

Vehicle:

other: no data

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: Glass and steel chamber
- Exposure chamber volume: 80 L
- System of generating particulates/aerosols: Air concentrations were generated using a ferris wheel generator to create a dust and passing clean air through the generator at 30 L/min to the chamber containing the animals.

TEST ATMOSPHERE (if not tabulated)
- Particle size distribution: Greater than 43 % of the dust particles were <5 μm in diameter, and >65% were less than 10 μm

Analytical verification of test atmosphere concentrations:

not specified

Duration of exposure:

4 h

Concentrations:

3.16 and 3.60 mg/l

No. of animals per sex per dose:

5

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC50

Effect level:

> 3.6 mg/L air

Exp. duration:

4 h

Mortality:

No deaths occurred at either test level

Clinical signs:

other: No untoward reactions were observed during the exposure.

Gross pathology:

no alterations were observed

Any other information on results incl. tables

No further details are reported.