1,1'-dithiobis[hexahydro-2H-azepin-2-one]

Endpoint summary

Additional information

Bioaccumulation: aquatic / sediment

No experimental data is available; however, the bioconcentration factor (BCF) of the test substance can be determined by the computer program BCFBAFWIN v3.00 (EPIWIN software) by US-EPA (Chemservice S.A., 2011). Using the regression-based estimate (traditional method) a Bioconcentration Factor (BCF) of 14.2 L/kg wet-wt was calculated. Using the Arnot-Gobas method, which is based on mechanistic first principles, an aquatic BCF of 19.9 L/kg wet-wt is the result. The experimentally determined logPow of 2.25 was taken into account for these predictions (White and Mullee, 2001, shake flask method, at 30 °C). The whole body primary biotransformation rate estimate for fish results in a half-life of 0.24 days, whereby the bio half-life is normalized to 10 g fish at 15 °C. The rate constant (kM) for 10 g fish is 2.91/day. This is taken into account to predict the apparent metabolism half-life in fish of the test substance. With the Arnot-Gobas method it is possible to differentiate between three trophic levels. For the lower trophic level the BCF results in 10.54 L/kg wet-wt, for a mid trophic level the result is 11.65 L/kg wet-wt and for the higher trophic level 15.62 L/kg wet-wt. No correction factors were applied.

Bioaccumulation: terrestrial

This information is not available and / or not required under REACH.