Registration Dossier
Registration Dossier
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EC number: 284-851-5 | CAS number: 84988-61-4
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
The genetic toxicity assessment of isononyl phosphate is based on read-across data from the structurally related substance 2-ethylhexyl phosphate (CAS 12645-31-7).
Reverse mutation assay 'Ames Test' using S. typhimurium and E. coli
No significant increases in the frequency of revertant colonies were recorded for any of the bacterial strains, with any dose of the test item, either with or without metabolic activation or exposure method. The test item was considered to be non-mutagenic under the conditions of this test.
Chromosome aberration test in human lymphocytes
The test item did not induce any statistically significant increases in the frequency of cells with aberrations, in either of two separate experiments, using a dose range that included a dose level that induced or exceeded the optimum 50% mitotic inhibition.
The test item was considered to be non-clastogenic to human lymphocytes in vitro.
CHO HPRT forward mutation assay
The test item demonstrated no significant increases in mutant frequency at any dose level, either with or without metabolic activation, in either the first or second experiment. The test item was considered to be non-mutagenic to CHO cells at the HPRT locus under the conditions of the test.
Justification for selection of genetic toxicity endpoint
All of the available in vitro studies were negative so no study has been selected.
Short description of key information:
The substance gave negative results in three different in vitro gentoxicity assays.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Based on negative results in the three seperate in vitro gentoxicity studies conducted on a related substance, the substance is not classified for mutagencity.
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