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Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

In a study performed to OECD guidelines and GLP (Huntingdon Life Sciences, 2014c; Klimisch score = 1), propylene glycol dibenzoate was determined to be readily biodegradable according to the "manometric respirometry test" (OECD 301F).

 

Annex IX of Regulation (EC) No 1907/2006, states that that long-term toxicity testing shall be proposed by the registrant if the results of the chemical safety assessment according to Annex I indicate the need to investigate further the effects of the substance and/or degradation products on terrestrial organisms.

 

There are no defined uses where direct exposure of this substance to the soil compartment is likely. Also, as this substance is readily biodegradable, it can be assumed that it will be biodegraded within the STP process and as a consequence indirect transfer to the soil compartment from sludge is not expected. Furthermore, the results from a read across earthworm study (Huntingdon Life Sciences, 1998e; Klimisch score = 1) have been used to assess the hazard to terrestrial organisms and further investigation of the effects of the substance and/or its breakdown products on additional terrestrial organisms is not justified and are waived.

 

Toxicity to soil macroorganisms except arthropods

There is no data available for propylene glycol dibenzoate (PGDB). Relevant information is available from a structural analogue Dipropylene glycol dibenzoate (DPGDB). The justification for read across is presented as an attachment included in Section 13 of the IUCLID dossier.

 

In an OECD Guideline 207 acute toxicity study in earthworms, conducted to determine the effects of DPGDB, no mortalities were observed and all worms were normal in appearance on days 7 and 14 of the test. Under the conditions of this study, the LC50 value of DPGDB to the earthworm was found to be in excess of 1000 ppm. The no observed effect level (NOEL) was considered to be 1000 ppm (Huntingdon Life Sciences, 1998e; Klimisch score = 1).

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