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EC number: 309-886-6 | CAS number: 101316-84-1 A tar obtained from low temperature carbonization and low temperature gasification of brown coal. Composed primarily of aliphatic, naphthenic and cyclic aromatic hydrocarbons, heteroaromatic hydrocarbons and cyclic phenols.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- other: Assessment from available information
- Adequacy of study:
- key study
- Study period:
- August - September 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Assessment report meets generally accepted scientific method.
Data source
Reference
- Reference Type:
- other: Final assessment report
- Title:
- Unnamed
- Year:
- 2 010
Materials and methods
Test guideline
- Qualifier:
- no guideline required
Test material
- Reference substance name:
- Tar, brown-coal, low-temp.
- EC Number:
- 309-886-6
- EC Name:
- Tar, brown-coal, low-temp.
- Cas Number:
- 101316-84-1
- Molecular formula:
- Not known - the substance is complex of hundreds organic compounds.
- IUPAC Name:
- Tar, brown-coal, low-temp.
- Details on test material:
- - Name of test material (as cited in study report): Tar, brown-coal, low-temp.
- Molecular formula: not known - UVCB substance
- Molecular weight: not known - UVCB substance
- Smiles notation: not known - UVCB substance
- InChl: not known - UVCB substance
- Substance type: technical product
- Physical state: viscous liquid
Constituent 1
Results and discussion
- Preliminary studies:
- No experimental data about absorption, distribution or excretion were found in literature. Due the complex composition of the substance is very difficult to estimate the behaviour of each individual component in addition of others components. It is evident that the behaviour of individual components in organisms could be interacted each another.
Applicant's summary and conclusion
- Executive summary:
Evaluation of toxicokinetics of the substance - Tar, brown-coal, low-temp. - was performed. It is required by the point 8.8.1 of Annex VIII to the Directive (EC) No. 1907/2006.
The test substance is characterized as UVCB substance and its composition is very complicated. No toxicokinetic data were found in the literature about the test substance. . Estimation of toxicokinetic behaviour of the substance was performed mainly according to experimental data from the results obtained by the toxicological testing.
After single oral administration of the substanceTar, brown-coal, low-temp.,to rats, no clinical symptoms of systemic intoxication were found out. The results did not allow to make the decision about absorption of the substance from digestive tract. If it is absorbed, the absorption occurs in such a doses, which do not allow the detection of toxicity symptoms in this type of acute toxicity test.
After single dermal application of the test substance to the skin of rats, no clinical signs of intoxication were recorded.After application of the test substance on ears of mice in the LLN assay, it showed a tendency to cause the increase in ear weight.The results did not allow to make the decision about the absorption of the substance through the skin. If it is absorbed, it occurs in such a doses, which do not allow the detection of toxicity symptoms in this type of acute toxicity test.
Aftersingle application of test substance to the skin of rabbits, systemic toxic effects were not detected – the conclusion is the same as stated above.
After single application of the substance to conjunctival sac of the rabbit eye,the highest degree of conjunctiva chemosis (value of 4) and conjunctiva redness (value of 3)appeared. Systemic toxic effects were not detected.The results did not allow to make the decision about the absorption of the substance through the skin. If it is absorbed, the absorption occurs in such a doses, which do not allow the detection of toxicity symptoms in this type of acute toxicity test.
When measuring the sensitization effect in the LLNA, the test substance Tar, brown-coal, low-temp caused a significant increase in radioisotope incorporation into the DNA of dividing lymphocytes in adjacent lymph node. This is the proof that the test substance penetrates at least through stratum corneum to epidermis. There is no indication that further penetration of the substance to the dermis and other tissues occurs, because no clinical signs of systemic intoxication were detected in this experiment. Similarly, theseresults did not allow to make the final decision about the absorption of the substance through the skin.
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