Registration Dossier
Registration Dossier
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EC number: 309-886-6 | CAS number: 101316-84-1 A tar obtained from low temperature carbonization and low temperature gasification of brown coal. Composed primarily of aliphatic, naphthenic and cyclic aromatic hydrocarbons, heteroaromatic hydrocarbons and cyclic phenols.
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
Assessment of the toxicokinetic behaviour of the test substance Tar, brown-coal, low-temp., from available information (literature search and existing study) was performed. No summary toxicokinetic study was found. No experimental data about absorption, distribution or excretion of the test substanceTar, brown-coal, low-temp.,were found in the literature. Due the complex composition of the substance, it is difficult to estimate the behaviour of each individual component. Behaviour of individual components of the test substance in living organisms could be affected by interaction among components.
In the 9thReport on Carcinogens (NIEHS, 2001), coal tars and coal tar pitches, and untreated and mildly treated mineral oils were listed as known human carcinogens based on sufficient evidence of carcinogenicity in humans. Data available deal mainly with the development of skin cancers. But there were also indications, that when applied to the skin, coal tar induced epidermoid lung carcinomas in rats. One study of millwrights and welders exposed to coal tars and coal tar pitch in a stamping plant showed significant excesses of leukemia and cancers of the lung and digestive organs (IARC S.7, 1987).
These data suggested that during the long-term exposure, the absorption of substances contained in the test substance could occur after dermal exposureInformation on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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