Dodecyloxirane

Short-term toxicity to fish

Description of key information

In a weight of evidence approach based on QSAR calculations the toxicity in fish was determined to be 0.105 mg/l. 

Key value for chemical safety assessment

Fresh water fish

Fresh water fish

Effect concentration:

0.105 mg/L

Additional information

No acute toxicity values are available for dodecyloxirane. A read across approach was performed with the structural supporting substance decyloxirane. Decyloxirane was investigated for acute tpoxicity to the guppy. Semi-static 14 day LC50 values were determined. At least 5 concentrations, geometrically increasing with a factor of 1.8, were tested for each compound, exposing 10 fish to each concentration. Actual concentrations of the toxicant were determined at least four times before and four times after renewal of the solutions for 2 concentrations of each compound. Concentra tions were determined using gas-liquid chromatography (GLC), which was carried out on a Tracor 550 chromatograph equipped with a flame ionization detector. Analyses were carried out by direct aqueous injection of water samples. LC50 values were calculated from log-logit analysis. The 14 day LC50 was estimated to 1.11 mg/L (Deneer, 1988) . Correlations with QSAR calcualtions indicate that the toxicity might even be higher than revealed in the experiment. Therefore, the test result is considered only as supporting study.

Additional QSAR calculations were performed to close this data gap. QSAR calculations with ECOSAR (version v.1.00, neutral organic_ baseline toxicity) and Catalogic (version 5.11.16) indicate for Dodecyloxirane a fish toxicity between 0.105 - 0.34 mg/l. The substances are covered by the applicability domaine of the QSAR tools for baseline toxicity.