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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Guideline study with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1983
Report date:
1983

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Deviations:
yes
Remarks:
no information on the test compound
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Propane-2-thiol
EC Number:
200-861-4
EC Name:
Propane-2-thiol
Cas Number:
75-33-2
Molecular formula:
C3H8S
IUPAC Name:
propane-2-thiol
Test material form:
liquid
Details on test material:
No details available

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Charles River laboratories, Inc.
- Age at study initiation: no data
- Weight at study initiation: 200-350 g
- Housing: individually
- Diet (ad libitum): Purina lab chow #5001
- Water (ad libitum): tap water
- Acclimation period: at least 7 days

ENVIRONMENTAL CONDITIONS
- Temperature (°F): 70 +/- 4
- Humidity (%): 40-60
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12/12

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
other: unchanged (no vehicle)
Details on inhalation exposure:
GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: glass and stainless steel chambers
- Exposure chamber volume: 38 liters
- Method of holding animals in test chamber: individually in stainless-steel wire-mesh cage
- Source and rate of air: 10 l/min
- System of generating vapors: water-jacketed counter-flow column maintained at ca. 80°F
- Treatment of exhaust air: no data
- Temperature, humidity in air chamber: 75 +/- 3°F, 50-70%

TEST ATMOSPHERE
- Brief description of analytical method used: Total hydrocarbon analysis
- Samples taken from breathing zone: no data
Analytical verification of test atmosphere concentrations:
yes
Remarks:
Total hydrocarbon analysis
Duration of exposure:
4 h
Concentrations:
22.55 mg/l (nominal)
10368.75 +/- 1202.66 ppm (32.24 mg/l, analytical)
No. of animals per sex per dose:
5
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations: during exposure and twice daily
- Body weight: prior exposure and on days 2,3, 4, 7 and 14
- Necropsy of survivors performed: yes
- Other examinations performed: no
Statistics:
Not appropriate

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC0
Effect level:
> 32.24 mg/L air (analytical)
Exp. duration:
4 h
Remarks on result:
other: > 10368 ppm, no mortality
Mortality:
No mortality was observed
Clinical signs:
other: Beginning 30 minutes after initiation of exposures, all animals exhibited hyperactivty and ataxia (for the first 3 hours of exposure), labored respiration, prostration (last 30 minutes of exposure), and squinted eyes. One male and two females had bloody c
Body weight:
The males exhibited reduced mean body weights through Day 4 post-exposure and the females exhibited reduced mean body weights through Day 7 post-exposure when compared to the respective pre-exposure mean body weights.
Gross pathology:
All animals appeared normal at the terminal sacrifice with the exception of one male observed with an enlarged left cervical lymph node.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Executive summary:

In a key study similar to OECD TG 403, Sprague-Dawley rats (5/sex) were exposed (whole-body) for four hours to propane-2-thiol at a measured concentration of 32.24 mg/l [10368 ppm]. Animals were observed for 14 days following the exposure. No mortality was observed. Beginning 30 minutes after initiation of exposures, all animals exhibited hyperactivty and ataxia, labored respiration, prostration, and squinted eyes. All animals appeared normal throughout the rest of the study with the exception of one female exhibiting urine stains through Day 3 postexposure. The males exhibited reduced mean body weights through Day 4 postexposure and the females exhibited reduced mean body weights through Day 7 postexposure. There was no evidence of macroscopic changes attributable to exposure. The 4-hour LC0 was > 32.24 mg/L (> 10368 pm).