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Ecotoxicological information

Long-term toxicity to aquatic invertebrates

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Description of key information

In a 21-day chronic toxicity study, Daphnia magna were exposed to D-Glucose, ether with glycerol at nominal concentrations of 0 (control), 10 mg/L under daily renewal conditions in accordance with the OECD 211 guideline. The nominal concentrations were:
LOEC > 10 mg/L
NOEC ≥ 10 mg/L
No significant mortality or any adverse effects on reproduction or additional endpoints (i.e. growth, immobile young, time to first brood, or aborted eggs) were observed in any of the test treatments.

Key value for chemical safety assessment

EC10, LC10 or NOEC for freshwater invertebrates:
10 mg/L

Additional information

In a 21-day chronic toxicity study, Daphnia magna were exposed to D-Glucose, ether with glycerol at nominal concentrations of 0 (control), 10 mg/L under daily renewal conditions in accordance with the OECD 211 guideline. The water pH, temperature and dissolved O2 were within acceptable guideline specifications. Mortality, reproduction and sublethal effects were observed daily. The following 21-day overall effect concentrations (mg/L) were obtained based on nominal concentrations:

LOEC > 10 mg/L

NOEC ≥ 10 mg/L

No significant mortality or any adverse effects on reproduction or additional endpoints (i.e. growth, immobile young, time to first brood, or aborted eggs) were observed in any of the test treatments. The test substance did not have an adverse chronic toxic effect on Daphnia magna up to 10 mg/L. The data were not sufficient to calculate ECx values. However based on best professional judgment, a 21-day EC0 ≥ 10 mg/L is estimated.

Since the overall mean measured concentrations of the test substance in the test solutions were within +20% of the nominal concentrations, the effect concentration can be expressed relative to the nominal concentration for the evaluation of the test substance. The results in this study are consistent with all validity criteria and the test is valid according to the guidelines of this study. No deviations from test guidelines or other incidents occurred during the course of the reported test which may have influenced the results.