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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Study period:
1980
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Scientifically acceptable study report.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1980
Report Date:
1980

Materials and methods

Principles of method if other than guideline:
according to BASF-internal standard
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Name of the test substance used in the study report: N,N-Diethyl-ethylendiamin

Test animals

Species:
mouse
Strain:
NMRI
Sex:
male/female
Details on test animals and environmental conditions:
A standardized animal laboratory diet was used.

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
water
Details on exposure:
Concentrations: 0.5 and 2.0% (G/V)
Application volume: 10 ml/kg
Doses:
50, 200 mg/kg
No. of animals per sex per dose:
5
Details on study design:
- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 50 - < 200 mg/kg bw
Mortality:
50 mg/kg: 0/5 after 14 days, 100 mg/kg: 5/5 after 14 days (male and female animals)
Clinical signs:
dyspnea, apathy, trembling, spastic gait, urine intense yellow, ruffled fur, exsiccosis, poor general state.
Body weight:
Mean body weights of male animals: at study start: 24 g (50 and 200 mg/kg), after 13 d 31.6 g (50 mg/kg).
Mean body weights of female animals: at study start: 22 g (50 and 200 mg/kg); after 13 d 25.4 g /50 mg/kg).
Gross pathology:
Animals that died and sacrificed animals: no intra-abdominal substance residues nor adhesions.

Applicant's summary and conclusion