2-methylbut-3-en-2-ol

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Comparable to guideline study with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1972

Report date:

1972

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

Deviations:

yes

Remarks:

tested below limit dose, no weighing after application

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

2-methylbut-3-en-2-ol

EC Number:

204-068-4

EC Name:

2-methylbut-3-en-2-ol

Cas Number:

115-18-4

Molecular formula:

C5H10O

IUPAC Name:

2-methylbut-3-en-2-ol

Details on test material:

- Name of test material (as cited in study report): 2-methylbut-3-en-2-ol
- Analytical purity: 98.5-99%
- Physical state: clear liquid

Test animals

Species:

rabbit

Strain:

Vienna White

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: mean 3.4 kg (male), 3.5 kg (female)

Administration / exposure

Type of coverage:

occlusive

Vehicle:

unchanged (no vehicle)

Details on dermal exposure:

TEST SITE
- Area of exposure: area of 354 cm2 on back of animals
- Type of wrap if used: covered by parchment-paper and collars


REMOVAL OF TEST SUBSTANCE
- Washing (if done): no


TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2 ml
- Concentration (if solution): 100%
- Constant volume or concentration used: yes

Duration of exposure:

24 h

Doses:

2000 mm3/ kg bw = 1640 mg/kg bw (calculated with a density of 0.82 g/mL; see chapter "Density")

No. of animals per sex per dose:

3

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: weighing prior to begin of study; observation several times during observation period
- Necropsy of survivors performed: yes

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 1 640 mg/kg bw

Based on:

test mat.

Remarks on result:

other: 2 ml/ kg bw = 1640 mg/kg bw (calculated with a density of 0.82 g/m)

Mortality:

no mortality

Clinical signs:

other: - after 1 h apathy; without symptoms after the 2nd day

Gross pathology:

yellow colour of the adipose tissue in 1 of 6 animals

Other findings:

- desquamation observed on 3 males; females without findings