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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
bioaccumulation in aquatic species: fish
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study according to EU/OECD guideline

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2002

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 305 (Bioconcentration: Flow-through Fish Test)
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
4-(methylthio)-3,5-xylenol
EC Number:
230-947-7
EC Name:
4-(methylthio)-3,5-xylenol
Cas Number:
7379-51-3
Molecular formula:
C9H12OS
IUPAC Name:
3,5-dimethyl-4-(methylsulfanyl)phenol
Radiolabelling:
yes

Test solutions

Vehicle:
yes

Test organisms

Test organisms (species):
Lepomis macrochirus

Study design

Route of exposure:
aqueous
Test type:
flow-through
Water / sediment media type:
natural water: freshwater
Total exposure / uptake duration:
28 d
Total depuration duration:
14 d

Results and discussion

Bioaccumulation factor
Type:
BCF
Value:
14.5 dimensionless
Basis:
whole body w.w.

Any other information on results incl. tables

The mean tissue residues (given in mg/kg fresh weight) at steady state are displayed in the following table:

30 ug [14C]- Methiocarb-phenol /L (based on trr)

Edible Parts:                                                         1 .33 mg/kg

Non Edible Parts:                                                  7.61 mg/kg

Whole Fish:                                                           3.79 mg/kg

The uptake rate constant (Ku), depuration rate constant (Kd), time for half clearance and the kinetic bioconcentration factors (based on trr) for edible parts and for whole fish were determined using the OriginTM non-linear kinetic modeling computer programme (2) for this bioconcentration study. The optimal parameter estimates were determined to be:

Origin Calculation Results                                          30 ug [14C]- Methiocarb-phenol/L (based on trr)

Parameter                                                                Edible Parts               Viscera                      Whole Fisch

Kinetic Bioconcentration Factor (BCFtrr)                     49.6                            262                            132

Time to Reach 95% of Steady-State (days)                     7.8                            3.0                            3.3

t(1/2) for Clearance (days)                                              1.8                            0.69                           0.77

Taking into account that in edible parts of the fish 15% of the TRR were identified as parent compound and in viscera 9% of the TRR the steady-state-BCF for parent (based on whole fish, wet weight) is 14.5, the steady-state-BCF for parent (normalised to 6% lipid content) is 10.9.

BCFparent (whole fish, wet weight)                                   14.5

BCFparent (whole fish, normalised to 6% lipid content)      10.9

Applicant's summary and conclusion

Validity criteria fulfilled:
yes