Registration Dossier

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: older study; non GLP

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Report Date:
1957

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
whole body
Vehicle:
air
Duration of exposure:
6 h
Concentrations:
0.97 mg/L (117 ppm); 2.91 mg/L (355 ppm)
No. of animals per sex per dose:
3
Control animals:
no
Details on study design:
airflow through compartment was 2L/min at either room temperature (117 ppm) or 100 deg. C (355 ppm)

Results and discussion

Preliminary study:
Atmospheric concentration of 2.91 mg/L of DMCD for 6 hours caused no symptoms or adverse effects
Effect levels
Sex:
not specified
Dose descriptor:
LC50
Effect level:
> 2.91 mg/L air (nominal)
Based on:
test mat.
Exp. duration:
6 h

Applicant's summary and conclusion

Interpretation of results:
relatively harmless
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
Atmospheric concentration of 2.91 mg/L of DMCD for 6 hours caused no symptoms or adverse effects
Executive summary:

In an acute inhalation experiment, 3 rats were exposed to a chamber concentration of 0.97 mg/L (117 ppm) for 6 hours, and a separate group of 3 rats were exposed to a chamber concentration of 2.91 mg/L (355 ppm) for 6 hours. At the end of the exposure period, there were no symptoms or adverse effects observed.