Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 265-088-7 | CAS number: 64741-86-2 A complex combination of hydrocarbons obtained by subjecting a petroleum distillate to a sweetening process to convert mercaptans or to remove acidic impurities. It consists of hydrocarbons having carbon numbers predominantly in the range of C9 through C20 and boiling in the range of approximately 150°C to 345°C (302°F to 653°F).
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
Workers - Hazard for the eyes
Additional information - workers
Workers: Other Gas Oils (Non-Carcinogenic)
| Effect | Route | DNEL | Dose Descriptor | Modified Dose Descriptor and Assessment Factors | |
| Acute Exposure | Systemic | Dermal | (a) | ||
| Inhalation | 5000 mg/m3/ 15 min (for lethality) [aerosol] | 1560 mg/m3/4 h (NOAEC based on lethality in acute inhalation study in rats) | Dose descriptor was modified to correct starting point of 16,723 mg/m3/15 min by adjustment for duration of exposure and level of activity. Then a total AF of 7.5 was applied for inter- and intraspecies differences. | ||
| Local | Dermal | (a) | |||
| Inhalation | (a) | ||||
| Long-Term Exposure | Systemic (b) | Dermal | 2.9 mg/kg/8h | 30 mg/kg/day (NOAEL based on on increased liver and spleen weights, altered bone marrow function (decreased haematopoiesis, red blood cell count, haemoglobin, and haematocrit) and liver histopathology in rats) | Dose descriptor was modified to correct starting point of 58.1 mg/kg/day by adjustment for dermal absorption.. Then a total AF of 24 was applied for subchronic to chronic and inter- and intraspecies differences. |
| Inhalation | 16 mg aerosol /m3/8h [aerosol] | 30 mg/kg/day (NOEL based on increased resorption, incomplete skeletal ossification, decreased foetal weights and decreased litter size in a dermal developmental toxicity study in rats with dosing on GD 0-19) | Dose descriptor was modified to correct starting point of 205.1 mg/m3/8 h by adjustment for dermal absorption, extrapolation from dermal to inhalation route, and ventilation in workers. Then a total AF of 7.5 was applied for inter- and intraspecies and remaining differences. | ||
| Local | Dermal | (a) for 13-wk exposures and | |||
| (c) for chronic exposures (dermal carcinogen) | |||||
| Inhalation | (a) |
a) No hazard identified for this route (data available)
b) Long-term systemic effects include non-reproductive effects and developmental/reproductive effects. Lowest DNEL is shown.
c) No-threshold effect and/or no dose-response information available
Worker: Carcinogenic or Unknown Other Gas Oils
|
Effect |
Route |
DNEL |
Dose Descriptor |
Modified Dose Descriptor and Assessment Factors |
Acute Exposure |
Systemic |
Dermal |
(a) |
|
|
Inhalation |
5000 mg/m3/ 15 min (for lethality) [aerosol] |
1560 mg/m3/4 h (NOAEC based on lethality in acute inhalation study in rats) |
Dose descriptor was modified to correct starting point of 16,723 mg/m3/15 min by adjustment for duration of exposure and level of activity. Then a total AF of 7.5 was applied for inter- and intraspecies differences. |
||
Local |
Dermal |
(a) |
|
|
|
Inhalation |
(a) |
|
|
||
Long-Term Exposure |
Systemic (b) |
Dermal |
2.9 mg/kg/8h |
30 mg/kg/day (NOAEL based onon increased liver and spleen weights, altered bone marrow function (decreased haematopoiesis, red blood cell count, haemoglobin, and haematocrit) and liver histopathologyin rats) |
Dose descriptor was modified to correct starting point of 58.1 mg/kg/day by adjustment for dermal absorption.. Then a total AF of 24 was applied for subchronic to chronic and inter- and intraspecies differences. |
Inhalation |
16 mg aerosol /m3/8h [aerosol] |
30 mg/kg/day (NOEL basedon increased resorption, incomplete skeletal ossification, decreased foetal weights and decreased litter sizein a dermal developmental toxicity study in rats with dosing on GD 0-19)
|
Dose descriptor was modified to correct starting point of 205.1 mg/m3/8 h by adjustment for dermal absorption, extrapolation from dermal to inhalation route, and ventilation in workers. Then a total AF of 7.5 was applied for inter- and intraspecies and remaining differences. |
||
Local |
Dermal |
(a) for 13-wk exposures and (c) for chronic exposures (dermal carcinogen) |
|
|
|
Inhalation |
(a) |
|
|
a) No hazard identified for this route (data available)
b) Long-term systemic effects include non-reproductive effects and developmental/reproductive effects. Lowest DNEL is shown.
c) No-threshold effect and/or no dose-response information available
General Population - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard via oral route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard for the eyes
Additional information - General Population
General Population Other Gas Oils
|
Effect |
Route |
DNEL |
Dose Descriptor |
Modified Dose Descriptor and Assessment Factors |
Acute Exposure |
Systemic |
Dermal |
(a) |
|
|
Inhalation |
3000 mg/m3/ 15 min (for lethality) [aerosol] |
1560 mg/m3/4 h (NOAEC based on lethality in acute inhalation study in rats) |
Dose descriptor was modified to correct starting point of 16,723 mg/m3/15 min by adjustment for duration of exposure and level of activity. Then a total AF of 7.5 was applied for inter- and intraspecies differences. |
||
Local |
Dermal |
(a) |
|
|
|
Inhalation |
(a) |
|
|
||
Long-Term Exposure |
Systemic (b) |
Dermal |
1.3 mg/kg/8h |
30 mg/kg/day (NOAEL based onon increased liver and spleen weights, altered bone marrow function (decreased haematopoiesis, red blood cell count, haemoglobin, and haematocrit) and liver histopathologyin rats) |
Dose descriptor was modified to correct starting point of 58.1 mg/kg/day by adjustment for dermal absorption.. Then a total AF of 24 was applied for subchronic to chronic and inter- and intraspecies differences. |
Inhalation |
4.8 mg aerosol /m3/8h [aerosol] |
30 mg/kg/day (NOEL basedon increased resorption, incomplete skeletal ossification, decreased foetal weights and decreased litter sizein a dermal developmental toxicity study in rats with dosing on GD 0-19)
|
Dose descriptor was modified to correct starting point of 205.1 mg/m3/8 h by adjustment for dermal absorption, extrapolation from dermal to inhalation route, and ventilation in workers. Then a total AF of 7.5 was applied for inter- and intraspecies and remaining differences. |
||
Local |
Dermal |
(a) for 13-wk exposures and (c) for chronic exposures (dermal carcinogen) |
|
|
|
Inhalation |
(a) |
|
|
a) No hazard identified for this route (data available)
b) Long-term systemic effects include non-reproductive effects and developmental/reproductive effects. Lowest DNEL is shown.
c) No-threshold effect and/or no dose-response information available
General Population Carcinogenic or Unknown Other Gas Oils
|
Effect |
Route |
DNEL |
Dose Descriptor |
Modified Dose Descriptor and Assessment Factors |
Acute Exposure |
Systemic
|
Dermal |
(a) |
|
|
Inhalation |
(a) |
|
|
||
Local |
Dermal |
(a) |
|
|
|
Inhalation |
(a) |
|
|
||
Long-Term Exposure |
Systemic (b) |
Dermal |
(a) |
|
|
Inhalation |
(a) |
|
|
||
Oral |
1.3 mg/kg/24h |
30 mg/kg/day (NOAEL based onon increased liver and spleen weights, altered bone marrow function (decreased haematopoiesis, red blood cell count, haemoglobin, and haematocrit) and liver histopathologyin rats)
|
Dose descriptor was modified to correct starting point of 41.5 mg/kg/24 h by adjustments for dermal absorption, dermal to oral route, and duration and frequency of daily dosing. Then AF of 40 was applied for inter- and intraspecies differences and for total duration. |
||
Local |
Dermal |
(a) |
|
|
|
Inhalation |
(a) |
|
|
a) No DNEL needed since no exposure expected
b) Long-term systemic effects include developmental/reproductive effects. Lowest DNEL is shown.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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