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EC number: 239-032-7 | CAS number: 14960-06-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 31 Aug 1999 to 02 Sep 1999
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- GLP compliance:
- yes
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Deriphat 160 C KPC
- Source: Henkel KGaA, Kepec
- Water solubility: Soluble
- Volatile at room temperature: No
- Content: 30 % aqueous solution
- Batch No.: 1091821/410
- Expiration date: 30 May 2001
- Appearance: Yellow-brown / liquid - Analytical monitoring:
- yes
- Vehicle:
- no
- Details on test solutions:
- PREPARATION OF TEST SOLUTION:
A clear stock solution was prepared with a target concentration of 0.5 g test substance / 250 mL M4 medium. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- - Common name: Water flea
- Source: BioInternational B.V. NJ Horn, Netherlands
- Feed: Green algae Scenedesmus subspicatus. Organisms were fed last 21 hours before the study initiation
- Lighting: ~900 Lux; 16h:8h light:dark regime
- Temperature: ~20 °C
- Medium: same as test
EPHIPPIEN-INCUBATION
- Lighting: ~4800 Lux / continuously
- Temperature: ~20 °C
- Test medium: same as test - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Test temperature:
- 21 °C
- pH:
- 7.9 - 8.2
- Dissolved oxygen:
- 97 to 98 % (oxygen content)
- Nominal and measured concentrations:
- - Nominal concentrations: 0 (control), 2, 4, 8, 16, and 32 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel: 100 mL glass beakers
- Type: Closed
- Fill volume: 50 mL
- No. of organisms per vessel: 10
- No. of vessels per concentration: 2
- Preparation: Correspondings aliquots of stock solution were taken while stirred continuously and pipetted into the test vessels. It was complemented with 40 mL volume of M4 medium to set the final volumes.
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Elendt M4 medium
- Culture medium different from test medium: No
OTHER TEST CONDITIONS
- Adjustment of pH:
- Photoperiod: 16 h light : 8 hours dark
- Light intensity: Approximately 900 lux
EFFECT PARAMETERS MEASURED
- Immobilisation: Immobilisation was recorded after 24 and 48 hours exposure. - Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 1.71 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality
- Remarks on result:
- other: The recovery of the test substance was approximately 60.5%. This effect value has been adjusted accordingly.
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 5.7 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: The recovery of the test substance was approximately 60.5%. This effect value has been adjusted accordingly.
- Duration:
- 48 h
- Dose descriptor:
- LC100
- Effect conc.:
- 19 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: The recovery of the test substance was approximately 60.5%. This effect value has been adjusted accordingly.
- Duration:
- 48 h
- Dose descriptor:
- LC0
- Effect conc.:
- < 1.2 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: The recovery of the test substance was approximately 60.5%. This effect value has been adjusted accordingly.
- Details on results:
- After 48 hours, immobility was observed from the lowest test concentration and increased in a dose-reponsive manner to full immobility at the highest test concentration. Due to a low analytical substance finding (<80 %) during incubation, the effect concentrations based on nominal concentrations were adjusted. Daphnids showed no abnormal behaviour during the test period. See 'Any other information on results incl. tables'.
- Results with reference substance (positive control):
- The 24-h EC50 of the reference substance potassium dichromate was 1.0 mg/L, thus ranged between 0.9 and 1.9 mg/L and therefore meets the validity criteria of the standard.
- Reported statistics and error estimates:
- The evaluation was carried out according to the Probit method.
- Validity criteria fulfilled:
- yes
Reference
Table: Immobilisation results
Concentration |
Replicate |
Number of immobilised daphnids |
|
After 24 h |
After 48 h |
||
0 |
1 |
0 |
0 |
2 |
0 |
0 |
|
2 |
1 |
1 |
1 |
2 |
0 |
2 |
|
4 |
1 |
0 |
1 |
2 |
0 |
4 |
|
8 |
1 |
0 |
4 |
2 |
0 |
3 |
|
16 |
1 |
2 |
9 |
2 |
3 |
9 |
|
32 |
1 |
5 |
10 |
2 |
7 |
10 |
Description of key information
The 48-h EC50 value is 1.71 mg a.i./L in aquatic invertebrates (Daphnia magna).
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 1.71 mg/L
Additional information
The acute toxicity to aquatic invertebrates was determined in a study according to EU Method C.2. in compliance with GLP criteria (Henkel KGaA, 1999). In this study daphnids (Daphnia magna, 20 per concentration) were exposed to nominal test concentrations of 0 (control), 2, 4, 8, 16, and 32 mg/L for 48 hours under static conditions, corresponding to concentrations of 0.6, 1.2, 1.8, 2.4, 4.8 and 9.6 mg a.i./L. Analytical confirmation of the test substances was determined by fluid chromatography with a diode-array-detector. The mean recovery rate of the test substance was found to be 60.5%. Effect values were adjusted accordingly. After 48 hours, immobility was observed from the lowest test concentration and increased in a dose-reponsive manner to full immobility at the highest test concentration. Based on the results, the 48-h EC50 was determined to be 1.71 mg a.i./L.
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