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Short-term toxicity to fish

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Reference
Endpoint:
short-term toxicity to fish
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
Please refer to chapter 13 for the read-across justification.
Reason / purpose for cross-reference:
read-across source
Key result
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
4.2 mg/L
Basis for effect:
mortality (fish)
Remarks on result:
other: test result from read-across source CAS 90170-43-7 (Huntingdon Research Centre Ltd., 1993).

Description of key information

A read across study for fish (Rainbow trout) is available. The 96-h LC50 value is 4.2 mg/L in fish (Ochorhynchus Mykiss).

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
4.2 mg/L

Additional information

Since no data on the short-term toxicity to fish of the test substance is available, the assessment is based on a study of the close structural analogue β-Alanine, N-(2-carboxyethyl)-, N-coco alkyl derivs., disodium salts (CAS 90170-43-7).

The short-term toxicity to freshwater fish was determined in a study according to OECD TG 203 and in compliance with GLP criteria (Huntingdon Research Centre Ltd., 1993). In this study, groups of 10 rainbow trout (Ochorhynchus mykiss) were exposed for 96 hours to nominal concentrations of 0.56, 1.0, 1.8, 3.2, 5.6 and 10 mg a.i./L (active ingredient) in a semi-static regime. No analytical monitoring of the test concentrations was performed during the test. Incidences of mortality and clinical effects were recorded after 3, 6, 24, 48, 72 and 96 hours exposure. All OECD validity criteria were met. At the test concentration of 5.6 mg/L, all fish had died after 24 hours exposure. At 3.2 mg/L, no mortality was observed during the whole exposure period. Only at the highest test concentration, loss of equilibrium was observed after 6 hours exposure. Based on these results, the 96-h LC50 was determined to be 4.2 mg a.i./L.