Registration Dossier
Registration Dossier
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EC number: 203-851-8 | CAS number: 111-26-2
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: scientifically acceptable study report
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 969
- Report date:
- 1969
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Hexylamine
- EC Number:
- 203-851-8
- EC Name:
- Hexylamine
- Cas Number:
- 111-26-2
- Molecular formula:
- C6H15N
- IUPAC Name:
- hexan-1-amine
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: Kisslegg mice
- Sex:
- male/female
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Details on exposure:
- The test concentrations were 0.5, 1, 2 and 20 % (v/v); aqueous emulsion with Traganth.
- Doses:
- 19, 38, 49, 61, 76, 95, 153, 1221 mg/kg bw
- No. of animals per sex per dose:
- 10 per dose level
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 53 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: original value: ca. 70 mm3/kg
- Mortality:
- 19 and 38 mg/kg: 2/10 after 7 days; 49 mg/kg: 3/10 after 7 days; 61 mg/kg: 7/10 after 7 days; 76 mg/kg: 5/10 after 7 days; 95 mg/kg: 9/10 after 7 days; 153 and 1221 mg/kg: 10/10 after 7 days
- Clinical signs:
- spasms, dyspena, apathy
- Gross pathology:
- adhesions in the liver region
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
