[1,2,4]Triazolo[1,5-c]pyrimidine, 2,2'-dithiobis[5-ethoxy-7-fluoro-

Particle size distribution (Granulometry)

Administrative data

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

Not reported

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Study conducted in accordance with generally accepted scientific principles, possibly with incomplete reporting or methodological deficiencies, which do not affect the quality of the relevant results.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2011

Report date:

2011

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Particle size analysis was performed using light obscuration. Analysis of a dust sample was performed using a Particle Sizing System Accusizer 780 equipped with an LE400-0.5 sensor.

GLP compliance:

not specified

Type of distribution:

volumetric distribution

Test material

Test material information

Constituent 1

Reference substance name:

5-ethoxy-2-({5-ethoxy-7-fluoro-[1,2,4]triazolo[1,5-c]pyrimidin-2-yl}disulfanyl)-7-fluoro-[1,2,4]triazolo[1,5-c]pyrimidine

EC Number:

695-187-4

Cas Number:

166524-75-0

Molecular formula:

C14H12F2N8O2S2

IUPAC Name:

5-ethoxy-2-({5-ethoxy-7-fluoro-[1,2,4]triazolo[1,5-c]pyrimidin-2-yl}disulfanyl)-7-fluoro-[1,2,4]triazolo[1,5-c]pyrimidine

Test material form:

other: dust

Details on test material:

- Name of test material (as cited in study report): DEDS
- Physical state: solid

Results and discussion

Particle size

Percentile:

D50

Remarks on result:

other: Migrated from fields under 'Mass median diameter' as D50 percentile. No source field for Standard deviation.

Any other information on results incl. tables

Table 1 Weight Fraction Analysis

Run	Weight % <63 µm (from sieve and Accusizer Analysis)	Weight % <250 µm (from sieve analysis)	Weight % 250 to 425 µm (from sieve analysis)	Weight % >425 µm (from sieve analysis)
1	15.9	96.5	3.5	0.0
2	12.4
3	17.6
Average	15.3

 

Table 2 Accusizer Data

The data reported in Table 2 has been normalised to account for the fact that the sample contained material above 250 µm.

<250 µm Sieve Portion - Run 1
Diameter (microns)	Particle Count	Volume (%)	Cumulative Volume (%)	Normalised Volume (%)	Normalised Cumulative Volume (%)
0.97258	34125	0.005	0.005	0.005	0.005
1.07741	36504	0.007	0.012	0.007	0.012
1.19353	37909	0.01	0.022	0.010	0.021
1.32218	37196	0.013	0.035	0.013	0.034
1.46468	37380	0.017	0.052	0.016	0.050
1.62255	36573	0.023	0.075	0.022	0.072
1.79744	32897	0.028	0.103	0.027	0.099
1.99117	29080	0.034	0.137	0.033	0.132
2.20578	25465	0.04	0.177	0.039	0.171
2.44353	22234	0.048	0.225	0.046	0.217
2.7069	19952	0.058	0.283	0.056	0.273
2.99965	18667	0.074	0.357	0.071	0.344
3.32186	17314	0.094	0.451	0.091	0.435
3.67989	16427	0.121	0.572	0.117	0.551
4.07652	15523	0.155	0.727	0.149	0.701
4.5159	15087	0.205	0.932	0.198	0.898
5.00264	14795	0.273	1.205	0.263	1.162
5.54183	14355	0.36	1.565	0.347	1.509
6.13915	13198	0.451	2.016	0.435	1.943
6.80084	16622	0.539	2.555	0.520	2.463
7.53386	10068	0.635	3.19	0.612	3.075
8.34588	8132	0.697	3.887	0.672	3.747
9.24542	6226	0.726	4.613	0.700	4.447
10.24191	4285	0.679	5.292	0.655	5.101
11.34581	2849	0.614	5.906	0.592	5.693
12.5687	1760	0.516	6.422	0.497	6.191
13.92338	1009	0.402	6.824	0.388	6.578
15.42408	616	0.333	7.157	0.321	6.899
17.08653	389	0.286	7.443	0.276	7.175
18.92817	218	0.218	7.661	0.210	7.385
20.9683	118	0.161	7.822	0.155	7.540
23.22832	106	0.196	8.018	0.189	7.729
25.73192	68	0.171	8.189	0.165	7.894
28.50538	45	0.154	8.343	0.148	8.043
31.57777	51	0.237	8.58	0.228	8.271
34.9813	43	0.272	8.852	0.262	8.533
38.75168	35	0.301	9.153	0.290	8.823
42.92844	45	0.525	9.678	0.506	9.330
47.55539	54	0.857	10.535	0.826	10.156
52.68104	65	1.402	11.937	1.352	11.507
58.35914	75	2.199	14.136	2.120	13.627
64.64924	79	3.149	17.285	3.036	16.663
71.61731	73	3.956	21.241	3.814	20.476
79.33642	91	6.705	27.946	6.464	26.940
87.88751	70	7.011	34.957	6.759	33.699
97.36028	70	9.531	44.488	9.188	42.886
107.8541	40	7.404	51.892	7.137	50.024
119.4788	48	12.079	63.971	11.644	61.668
132.3566	37	12.568	76.629	12.202	73.870
146.6223	21	9.766	86.395	9.414	83.285
162.4257	12	7.587	93.982	7.314	90.599
179.9324	7	6.016	99.998	5.799	96.398
199.326	0	0	99.998	0.000	96.398
220.8099	0	0	99.998	0.000	96.398
244.6093	0	0	99.998	0.000	96.398
270.974	0	0	99.998	0.000	96.398
300.1803	0	0	99.998	0.000	96.398
330.4139	0	0	99.998	0.000	96.398

Applicant's summary and conclusion

Conclusions:

Weight fraction analysis of the ‘as received’ test material resulted in a weight % <63 µm (from sieve and Accusizer Analysis) of 15.3 %. The following values were obtained from sieve analysis only: weight % <250 µm was 96.5; weight % 250 to 425 µm was 3.5; weight % >425 µm was 0.0.

Executive summary:

Particle size analysis was performed using light obscuration. Analysis of the test material was performed using a Particle Sizing System Accusizer 780 equipped with an LE400-0.5 sensor.

The 'as received' samples were sieved using a 425 µm sieve in order to determine the weight percent less than 425 µm. An additional sieve analysis was performed to remove particles greater than 250 µm and the less than 250 µm portion of the sample was analysed using the Accusizer particle size analyser.

The Accusizer data was combined with the sieve analyses to obtain the weight percent of the samples less than 63 µm and the size distribution of those particles less than 63 µm.

 

Weight fraction analysis of the ‘as received’ sample resulted in a weight % <63 µm (from sieve and Accusizer Analysis) of 15.3 %. The following values were obtained from sieve analysis only: weight % <250 µm was 96.5; weight % 250 to 425 µm was 3.5; weight % >425 µm was 0.0.