Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
3 Sep. 2012
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2013
Report Date:
2013

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient)
GLP compliance:
no
Type of method:
shake-flask method to: flask method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
0.92
Temp.:
25 °C
pH:
9.1

Any other information on results incl. tables

Individual results:

Flask 1: Initially 20 mL octanol+20 mL water; in oct. 329.1 mg/L, in water 39.6 mg/L (pH 9.1)

Flask 2: Initially 20 mL octanol+20 mL water; in oct. 333.2 mg/L, in water 42.30 mg/L (pH 9.1)

Flask 3: Initially 40 mL octanol+20 mL water; in oct. 347.3 mg/L, in water 42.58 mg/L (pH 9.1)

Flask 4: Initially 40 mL octanol+20 mL water; in oct. 352.9 mg/L, in water 42.77 mg/L (pH 9.1)

Flask 5: Initially 80 mL octanol+20 mL water; in oct. 359.7 mg/L, in water 41.92 mg/L (pH 9.1)

Flask 6: Initially 80 mL octanol+20 mL water; in oct. 361.3 mg/L, in water 41.59 mg/L (pH 9.1)

 

Pow

logPow

Recovery rate (%)

Flask 1

8.31

0.92

95.5

Flask 2

7.88

0.90

97.3

Flask 3

8.16

0.91

95.5

Flask 4

8.25

0.92

97.0

Flask 5

8.58

0.93

95.9

Flask 6

8.69

0.94

96.3

mean

8.31

0.92

 

Std. dev.

0.29

0.01

 

final result for logPow (confidence 95%, k = 2): 0.92 ± 0.03

Applicant's summary and conclusion